van de Vijver L P, van Poppel G, van Houwelingen A, Kruyssen D A, Hornstra G
Department of Epidemiology, TNO Nutrition and Food Research, Zeist, Netherlands.
Atherosclerosis. 1996 Sep 27;126(1):155-61. doi: 10.1016/0021-9150(96)05906-0.
A high intake of trans fatty acids (TFAs) has been shown to have an undesirable effect on serum lipid profiles and lipoprotein(a) (Lpa)) levels and may thereby increase the risk for coronary heart disease (CHD). We performed a study in CHD patients, and measured the TFA concentration of the plasma phospholipid fraction. Comparison was made between a case group with angiographically documented severe CHD (> 80% stenosis in one coronary vessel, n = 83) and a control group of patients who had just minor stenosis on the coronary angiography (< 50% stenosis in all three major vessels, n = 78): All subjects were under 68 years of age and were prestratified on age, gender and smoking habits. The two groups were comparable according to the prestratification criteria, body mass index, blood pressure, number of cigarettes smoked and total fat intake. Controls had higher plasma HDL levels (P < 0.001) and lower, albeit not significantly lower, (P = 0.07) plasma LDL levels. No significant correlations were found between percentages of TFAs in plasma phospholipids and plasma LDL or HDL cholesterol levels. Of the major fatty acid classes, only the percentage of saturated fatty acids was significantly higher in cases (46.2 +/- 0.92%) than in controls (45.8 +/- 1.07% (means +/- S.D.)). The difference in total TFA content between cases and controls (0.32 +/- 0.02% versus 0.35 +/- 0.02%) was -0.03% (P = 0.2). For the specific TFAs C16:1n-7tr, C18:1n-9tr and C18: 2n-6tr, just minor differences were found. Adjusted odds ratios for tertiles of TFA percentages were 0.56 (0.25-1.23) and 0.76 (0.36-1.61) for the highest middle tertile compared to the lowest. These findings do not support an association between TFA intake and risk for coronary heart disease.
大量摄入反式脂肪酸（TFA）已被证明会对血清脂质谱和脂蛋白（a）[Lp（a）]水平产生不良影响，进而可能增加冠心病（CHD）风险。我们对冠心病患者进行了一项研究，并测量了血浆磷脂部分的TFA浓度。将血管造影记录显示患有严重冠心病（一根冠状动脉狭窄>80%，n = 83）的病例组与冠状动脉造影仅有轻度狭窄（三根主要血管狭窄均<50%，n = 78）的对照组进行比较：所有受试者年龄均在68岁以下，且根据年龄、性别和吸烟习惯进行了预先分层。根据预先分层标准、体重指数、血压、吸烟数量和总脂肪摄入量，两组具有可比性。对照组的血浆高密度脂蛋白（HDL）水平较高（P<0.001），血浆低密度脂蛋白（LDL）水平较低，尽管差异不显著（P = 0.07）。血浆磷脂中TFA的百分比与血浆LDL或HDL胆固醇水平之间未发现显著相关性。在主要脂肪酸类别中，只有饱和脂肪酸的百分比在病例组（46.2±0.92%）中显著高于对照组（45.8±1.07%（均值±标准差））。病例组和对照组之间的总TFA含量差异为-0.03%（0.32±0.02%对0.35±0.02%）（P = 0.2）。对于特定的TFA，如C16:1n-7tr、C18:1n-9tr和C18:2n-6tr，仅发现微小差异。与最低三分位数相比，TFA百分比最高的中间三分位数的调整优势比分别为0.56（0.25 - 1.23）和0.76（0.36 - 1.61）。这些发现不支持TFA摄入量与冠心病风险之间存在关联。
