Rudolph R, Guber S, Suzuki M, Woodward M
Surg Gynecol Obstet. 1977 Sep;145(3):389-94.
Myofibroblasts in pig granulating wounds have an identifiable life cycle that parallels the eight week span of contraction of the wounds. As seen by electron microscopy, fibroblasts with a contractile appearance became prominent within one week after wounding and persisted for 12 weeks, after which time they were not visible. Large tangled filaments, measuring 120 Angstrom units are prominent in fibroblasts in late contracted wounds and may be actin. Such filaments could preserve fibroblasts in a contracted state and allow time for the reorganization of collagen into a fixed rigid scar.
猪肉芽创面中的肌成纤维细胞具有可识别的生命周期，与创面八周的收缩期平行。通过电子显微镜观察，具有收缩外观的成纤维细胞在受伤后一周内变得突出，并持续12周，之后便不可见。在晚期收缩创面的成纤维细胞中，直径为120埃单位的粗大缠结细丝很突出，可能是肌动蛋白。这些细丝可使成纤维细胞保持收缩状态，并为胶原蛋白重组为固定的坚硬瘢痕留出时间。
