Seemayer T A, Lagacé R, Schürch W
Virchows Arch A Pathol Anat Histol. 1980;385(3):283-91. doi: 10.1007/BF00432538.
Ten cases of nodular sclerosing Hodgkin's disease involving lymph nodes were studied by electron microscopy to determine the ultrastructural composition of the nodule-stromal interphase and the collagenized regions. In addition to a few lymphocytes, rare eosinophils and neutrophils, abundant filamentous and granular electron dense material, collagen fibers and myofibroblasts were observed in all instances. Since myofibroblasts possess contractile and synthetic properties, it is likely they contribute to the retraction and sclerosis which together represent one of the morphologic hallmarks of the disease. The dense fibrosis and contractile state of such tissue may constitute a beneficial host response to contain and limit local and vascular invasion by the neoplastic cellular population, thus contributing to the relative benignity of this form of Hodgkin's disease.
对10例累及淋巴结的结节硬化型霍奇金病进行了电子显微镜研究，以确定结节-基质界面和胶原化区域的超微结构组成。除了少数淋巴细胞、罕见的嗜酸性粒细胞和中性粒细胞外，在所有病例中均观察到丰富的丝状和颗粒状电子致密物质、胶原纤维和成肌纤维细胞。由于成肌纤维细胞具有收缩和合成特性，它们很可能导致了退缩和硬化，而退缩和硬化共同构成了该疾病的形态学特征之一。这种组织的致密纤维化和收缩状态可能构成一种有益的宿主反应，以遏制和限制肿瘤细胞群体的局部和血管侵袭，从而促成这种形式的霍奇金病的相对良性。
