Rudolph R
Plast Reconstr Surg. 1979 Apr;63(4):473-80. doi: 10.1097/00006534-197904000-00005.
The myofibroblast population was studied by electron microscopy in rat wounds healing by (1) contraction of granulation tissue, (2) by coverage with split-skin grafts, and (3) by coverage with full-thickness skin grafts. In all 3 types of wounds, myofibroblasts appeared early and reached a peak number at two weeks after wounding. At this time, 40 to 50 percent of the wound fibroblasts had myofibroblast characteristics. The granulating wounds contracted rapidly and completely, and had long persistence of myofibroblasts. Split-skin grafted wounds contracted less and had a more rapid decrease in myofibroblasts. The wounds covered with full thickness skin grafts had a minimum of contraction with a very rapid decrease in the number of myofibroblasts until by 4 weeks no myofibroblasts were present. Full-thickness skin grafts thus appeared to influence contracting wounds not by preventing the formation of myofibroblasts, but by speeding up completion of their life cycle.
通过电子显微镜对大鼠伤口愈合过程中的肌成纤维细胞群体进行了研究，这些伤口的愈合方式分别为：（1）肉芽组织收缩；（2）用断层皮片覆盖；（3）用全厚皮片覆盖。在所有这三种类型的伤口中，肌成纤维细胞出现较早，并在受伤后两周达到数量峰值。此时，40%至50%的伤口成纤维细胞具有肌成纤维细胞特征。肉芽创面迅速且完全收缩，肌成纤维细胞持续存在的时间较长。断层皮片移植的伤口收缩较少，肌成纤维细胞数量下降更快。全厚皮片覆盖的伤口收缩最小，肌成纤维细胞数量迅速减少，到4周时已不存在肌成纤维细胞。因此，全厚皮片似乎不是通过阻止肌成纤维细胞的形成来影响收缩性伤口，而是通过加速其生命周期的完成来实现的。
