Yashon D, Brown R J, Hunt W E
Surg Neurol. 1977 Aug;8(2):111-5.
The action of six prostaglandins A1, E1, (A2, E2, F1 alpha, F2 alpha) on in vitro human basilar artery circumferential strips was evaluated to assess relative vasoreactivity. Degree of contraction was compared with 5-hydroxytryptamine (5-HT), hitherto the most active in this laboratory. The three most vasoactive prostaglandins were E1, E2, and F2, alpha. The three PGs giving highest magnitude of response were F1 alpha, F2 alpha, and E2. Most were more active when compared to 5-HT. Vasodilation did not occur. Because of their vasoconstrictive qualities, prostaglandins may participate in arterial vasospasm. It is postulated that prolonged vasoconstriction may lead to vasospasm and that the latter may result from one or more autacoids acting along or synergistically.
评估了六种前列腺素A1、E1、（A2、E2、F1α、F2α）对体外人基底动脉环行条的作用，以评估相对血管反应性。将收缩程度与5-羟色胺（5-HT）进行比较，5-HT是迄今为止本实验室中活性最高的。三种血管活性最强的前列腺素是E1、E2和F2α。产生最大反应幅度的三种前列腺素是F1α、F2α和E2。与5-HT相比，大多数前列腺素活性更高。未出现血管舒张。由于其血管收缩特性，前列腺素可能参与动脉血管痉挛。据推测，长时间的血管收缩可能导致血管痉挛，而后者可能是由一种或多种自身活性物质单独作用或协同作用引起的。
