Gabbiani G
CMU-Department of Pathology, University of Geneva, Switzerland.
Pathol Res Pract. 1996 Jul;192(7):708-11. doi: 10.1016/S0344-0338(96)80092-6.
The presence of myofibroblasts in granulation tissue and various fibrotic settings is well established. Recent work on this cell has shown that myofibroblasts derive mainly from local fibroblasts, but also from pericytes and smooth muscle cells as well as from specialized cells such as perisinusoidal stellate cells of the liver and mesangial cells of the kidney glomerulus. During the healing of an open wound, myofibroblasts disappear by means of apoptosis when the wound is closed and granulation tissue gradually transforms into scar tissue. The possibility exists that an altered regulation of this process leads to the development of a hypertrophic scar.
肌成纤维细胞在肉芽组织和各种纤维化环境中的存在已得到充分证实。关于这种细胞的最新研究表明，肌成纤维细胞主要来源于局部成纤维细胞，但也来源于周细胞和平滑肌细胞，以及诸如肝脏的窦周星状细胞和肾小球系膜细胞等特殊细胞。在开放性伤口愈合过程中，当伤口闭合且肉芽组织逐渐转化为瘢痕组织时，肌成纤维细胞通过凋亡消失。这种过程的调节改变有可能导致肥厚性瘢痕的形成。
