Watne A L, Lai H Y, Carrier J, Coppula W
Surgery. 1977 Sep;82(3):327-33.
Of one hundred and twenty-six patients with Gardner's syndrome, 60% showed soft tissue tumors, 32% showed osteomatosis, 67% polyposis, and 20% the complete triad. Bowel cancer developed in 32% of the patients. The frequency of other diseases in these patients showed fibrous tumors in 8%, and two patients with cancer of the ampulla of Vater; otherwise the diseases seen did not show any major variation from what might be expected for the group at risk. Laboratory evaluation has included the demonstration of increased fecal cholesterol and primary bile acids in these patients. The recommended surgical treatment is colectomy and ileorectal anastomosis at a measured 12 cm level. This level of ileorectal anastomosis may be vital in giving a regression of rectal polyps, which was seen in 15 to 17 patients so treated. The conversion of an ileosigmoid to an ileorectal anastomosis resulted in polyp regression in one patient. The oral administration of ascorbic acid gave polyp regression in seven of 10 patients. There may be a possible relationship of fecal coprostanol and cholesterol levels and polyp regression.
在126例加德纳综合征患者中，60%出现软组织肿瘤，32%出现骨瘤病，67%出现息肉病，20%出现完整三联征。32%的患者发生了肠癌。这些患者中其他疾病的发生率为8%出现纤维瘤，还有2例患 Vater壶腹癌；除此之外，所见到的疾病与高危人群预期的情况相比没有任何重大差异。实验室评估包括证明这些患者粪便中胆固醇和初级胆汁酸增加。推荐的手术治疗是在12厘米处进行结肠切除术和回直肠吻合术。这种回直肠吻合水平对于使直肠息肉消退可能至关重要，在15至17例接受该治疗的患者中可见到息肉消退。将回乙状结肠吻合改为回直肠吻合使1例患者的息肉消退。口服抗坏血酸使10例患者中的7例息肉消退。粪便粪甾烷醇和胆固醇水平与息肉消退之间可能存在某种关系。
