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吸烟和饮酒作为胶质瘤的风险因素:澳大利亚墨尔本的一项病例对照研究。

Tobacco smoking and alcohol consumption as risk factors for glioma: a case-control study in Melbourne, Australia.

作者信息

Hurley S F, McNeil J J, Donnan G A, Forbes A, Salzberg M, Giles G G

机构信息

Department of Social and Preventive Medicine, Monash University, Victoria, Australia.

出版信息

J Epidemiol Community Health. 1996 Aug;50(4):442-6. doi: 10.1136/jech.50.4.442.

DOI:10.1136/jech.50.4.442
PMID:8882229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1060316/
Abstract

OBJECTIVE

To investigate possible associations between tobacco smoking and alcohol consumption and the risk of adult glioma.

DESIGN

This was a population based, case-control study. Relative risks (RR) were estimated using logistic regression analysis.

SETTING

Melbourne, Australia.

PARTICIPANTS

These comprised 416 case subjects (166 women, 250 men), 66% of those eligible; and 422 control subjects (170 women, 252 men), 43.5% of those potentially eligible.

RESULTS

There was no increase in risk of glioma with having ever smoked tobacco (RR 1.29, 95% CI 0.95, 1.75) for all subjects, adjusted for age, a reference date, and gender. There was a slight increase in risk for men (RR 1.64, 95% CI 1.1, 2.45), but not for women (RR 0.99, 95% CI 0.62, 1.62). For men, there was no increase in risk with increasing pack-years of cigarette smoking, but the risk was significantly increased in subjects who had smoked for less than 10 years. There was no increase in risk associated with having ever drunk alcohol for all subjects (RR 0.96, 95% CI 0.67, 1.37), women (RR 0.69, 95% CI 0.4, 1.15) or men (RR 1.40, 95% CI 0.81, 2.43).

CONCLUSIONS

This study does not support an association between either tobacco smoking or alcohol consumption and glioma. The pattern of risk associated with tobacco smoking in men appears inconsistent with a causal role, and may be due to chance, response bias, or uncontrolled confounding.

摘要

目的

探讨吸烟和饮酒与成人胶质瘤风险之间可能存在的关联。

设计

这是一项基于人群的病例对照研究。使用逻辑回归分析估计相对风险(RR)。

地点

澳大利亚墨尔本。

参与者

包括416例病例受试者(166名女性,250名男性),占符合条件者的66%;以及422名对照受试者(170名女性,252名男性),占潜在符合条件者的43.5%。

结果

在对年龄、参考日期和性别进行调整后,所有受试者中,曾经吸烟的人患胶质瘤的风险没有增加(RR 1.29,95%可信区间0.95,1.75)。男性的风险略有增加(RR 1.64,95%可信区间1.1,2.45),但女性没有增加(RR 0.99,95%可信区间0.62,1.62)。对于男性,吸烟包年数增加并没有使风险增加,但吸烟少于10年的受试者风险显著增加。所有受试者(RR 0.96,95%可信区间0.67,1.37)、女性(RR 0.69,95%可信区间0.4,1.15)或男性(RR 1.40,95%可信区间0.81,2.43)中,曾经饮酒与风险增加无关。

结论

本研究不支持吸烟或饮酒与胶质瘤之间存在关联。男性中与吸烟相关的风险模式似乎与因果作用不一致,可能是由于偶然因素、反应偏倚或未控制的混杂因素。

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