口服9-顺式维甲酸与13-顺式维甲酸治疗痤疮的对比
Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy.
作者信息
Ott F, Bollag W, Geiger J M
机构信息
F. Hoffmann-La Roche Ltd, Basel, Switzerland.
出版信息
Dermatology. 1996;193(2):124-6. doi: 10.1159/000246226.
BACKGROUND
9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters.
OBJECTIVE
Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study.
METHODS
Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses.
RESULTS
No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA.
CONCLUSION
For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.
背景
9-顺式维甲酸（9-cis-RA）在抑制培养的人皮脂腺细胞增殖以及减小仓鼠皮脂腺大小方面与13-顺式维甲酸（13-cis-RA）活性相当。
目的
在一项初步研究中评估9-顺式维甲酸与13-顺式维甲酸相比的抗痤疮效果。
方法
4名患有痤疮的年轻男性患者在一项开放性研究中连续接受相似剂量的9-顺式维甲酸和13-顺式维甲酸治疗。
结果
9-顺式维甲酸在任何患者中均未观察到有益效果，而所有患者对13-顺式维甲酸反应良好。
结论
对于所测试的两种维甲酸，抗痤疮效果与对人类的皮脂抑制作用相关。
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