Nguyen Kelvin, Van Nguyen Thai, Shen Duke, Xia Victor, Tran Diep, Banh Khanh, Ruan Victor, Hu Ke-Qin
Department of Medicine, University of California, Irvine Medical Center, Orange, CA, USA.
J Immigr Minor Health. 2015 Feb;17(1):13-20. doi: 10.1007/s10903-013-9975-5.
The prevalence of hepatitis B virus (HBV) infection is reportedly high in Vietnamese Americans (VAs), but most previous studies did not assess full HBV serology, and not the prevalence of HBV and hepatitis C virus (HCV) infection simultaneously. The aim of the study is to assess the prevalence of different HBV serologies and HCV infection in VAs. This study was based on the data collected by testing for Hepatitis B surface antigen (HBsAg), anti-hepatitis B core antibody (HBcAb IgG), anti-HBs antibody (HBsAb), and anti-HCV antibody (anti-HCV) in a series of community screening in VAs in Orange County, California. In 1,405 VA participants, the mean age was 51 (17-87) years, 45.1% were males; 68.2%, married; 97.2%, born in Vietnam. Most of the participants were non-US born with their primary language being non-English and with limited access to health care. Of the 1,405 cases, 124 (8.8%) were confirmed HBV infection by HBsAg+; 81 (5.8%), HCV infection by anti-HCV+; including four (0.3%) with HBV/HCV coinfection. Twelve percent of the participants with confirmed HBV infection thought they were previously tested negative, while 29.7% of the participants with confirmed HCV infection thought they were previously tested negative. In this cohort, 15.4% were HBsAg-/HBsAb-/HBcAb IgG-, i.e. being susceptible to HBV infection. In HCV infected participants, 65.4% were born between 1945 and 1965. This large serial survey and screening in the Vietnamese American community confirmed the rates of HBV and HCV infection to be as high as 8.8% and 5.8%, respectively. We have also identified factors related to HBV and HCV infection in this high-risk population.
据报道，越南裔美国人（VAs）中乙肝病毒（HBV）感染率很高，但之前的大多数研究并未评估完整的HBV血清学情况，也未同时评估HBV和丙型肝炎病毒（HCV）感染率。本研究的目的是评估VAs中不同HBV血清学情况及HCV感染率。本研究基于在加利福尼亚州奥兰治县对VAs进行的一系列社区筛查中检测乙肝表面抗原（HBsAg）、抗乙肝核心抗体（HBcAb IgG）、抗HBs抗体（HBsAb）和抗HCV抗体（抗HCV）所收集的数据。在1405名VA参与者中，平均年龄为51岁（17 - 87岁），45.1%为男性；68.2%已婚；97.2%出生于越南。大多数参与者非美国出生，母语非英语，且获得医疗保健的机会有限。在这1405例病例中，124例（8.8%）通过HBsAg阳性确诊为HBV感染；81例（5.8%）通过抗HCV阳性确诊为HCV感染；包括4例（0.3%）HBV/HCV合并感染。12%确诊为HBV感染的参与者认为他们之前检测为阴性，而29.7%确诊为HCV感染的参与者认为他们之前检测为阴性。在这个队列中，15.4%为HBsAg阴性/HBsAb阴性/HBcAb IgG阴性，即易感染HBV。在HCV感染的参与者中，65.4%出生于1945年至1965年之间。在越南裔美国社区进行的这项大规模系列调查和筛查证实，HBV和HCV感染率分别高达8.8%和5.8%。我们还确定了这个高危人群中与HBV和HCV感染相关的因素。
