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肺炎衣原体的生长可诱导人单核细胞系中细胞因子的产生及CD14的表达。

Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line.

作者信息

Heinemann M, Susa M, Simnacher U, Marre R, Essig A

机构信息

Abteilung für Medizinische Mikrobiologie und Hygiene, Universitat Ulm,Germany.

出版信息

Infect Immun. 1996 Nov;64(11):4872-5. doi: 10.1128/iai.64.11.4872-4875.1996.

DOI:10.1128/iai.64.11.4872-4875.1996
PMID:8890256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174462/
Abstract

Chlamydia pneumoniae was able to survive and to multiply in the human monocytic cell line Mono Mac 6. Growth of C. pneumoniae induced production of tumor necrosis factor alpha, interleukin 1beta, and interleukin 6, as well as up-regulation of the CD14 molecule in a time-dependent manner. Infection of monocytic cells and a proinflammatory cytokine response may be important in C. pneumoniae pathogenesis.

摘要

肺炎衣原体能够在人单核细胞系Mono Mac 6中存活并繁殖。肺炎衣原体的生长以时间依赖性方式诱导肿瘤坏死因子α、白细胞介素1β和白细胞介素6的产生，以及CD14分子的上调。单核细胞感染和促炎细胞因子反应可能在肺炎衣原体发病机制中起重要作用。

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