Braun J, Laitko S, Treharne J, Eggens U, Wu P, Distler A, Sieper J
Department of Medicine, Klinikum Steglitz, Free University of Berlin, Germany.
Ann Rheum Dis. 1994 Feb;53(2):100-5. doi: 10.1136/ard.53.2.100.
To examine whether reactive arthritis (ReA) known to occur after a urogenital infection with Chlamydia trachomatis can also follow an infection with Chlamydia pneumoniae, a recently described species of Chlamydiae that is a common cause of respiratory tract infections.
Specific antibodies (microimmunofluorescence test) and lymphocyte proliferation to C trachomatis and C pneumoniae in paired samples of peripheral blood and synovial fluid were investigated in 70 patients with either reactive arthritis (ReA) or undifferentiated oligoarthritis (UOA).
Five patients with acute ReA after an infection with C pneumoniae are reported. Three had a symptomatic preceding upper respiratory tract infection and two had no such symptoms. In all patients a C pneumoniae-specific lymphocyte proliferation in synovial fluid and a high specific antibody titre suggesting an acute infection was found.
C pneumoniae needs to be considered a new important cause of reactive arthritis.
探讨泌尿生殖系统沙眼衣原体感染后已知会发生的反应性关节炎（ReA）是否也可继发于肺炎衣原体感染，肺炎衣原体是衣原体属中最近描述的一个菌种，是呼吸道感染的常见病因。
对70例反应性关节炎（ReA）或未分化少关节炎（UOA）患者的外周血和滑液配对样本中针对沙眼衣原体和肺炎衣原体的特异性抗体（微量免疫荧光试验）及淋巴细胞增殖情况进行研究。
报告了5例肺炎衣原体感染后发生急性ReA的患者。3例在出现症状之前有上呼吸道感染，2例无此类症状。在所有患者中，均发现滑液中有肺炎衣原体特异性淋巴细胞增殖以及提示急性感染的高特异性抗体滴度。
肺炎衣原体应被视为反应性关节炎的一个新的重要病因。
