Ahmed A A, Nordlind K, Schultzberg M, Brakenhoff J, Bristulf J, Novick D, Svenson S B, Azizi M, Lidén S
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Acta Derm Venereol. 1996 Sep;76(5):348-52. doi: 10.2340/0001555576348352.
Immunoreactivity to interleukin-1 alpha, interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha and their receptors, as well as the endogenous interleukin-1 receptor antagonist, was investigated in hair follicles in paraffin-embedded normal human skin. Interleukin-1 beta- and tumour necrosis factor-alpha-like immunoreactivities were found in the inner root sheath layer of hair follicles, at the suprapapillary level. Interleukin-1 receptor-like immunoreactivity was also found in this layer, while there was a variable immunoreactivity to the interleukin-1 receptor antagonist. In the outer root sheath there was a weak to moderate staining for the four cytokines, in addition to intense staining for their receptors and a weak staining for the antagonist. The fibrous root sheath had a moderate immunoreactivity for interleukin-1 alpha and interleukin-6. The distribution patterns suggest that these cytokines, particularly interleukin-1 beta and tumour necrosis factor-alpha, may have a protective role in hair formation, while all the investigated proinflammatory cytokines may have a role in the differentiation process.
在石蜡包埋的正常人皮肤毛囊中，研究了白细胞介素-1α、白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α及其受体以及内源性白细胞介素-1受体拮抗剂的免疫反应性。在毛囊内根鞘层乳头上方水平发现了白细胞介素-1β和肿瘤坏死因子-α样免疫反应性。在该层中也发现了白细胞介素-1受体样免疫反应性，而对白细胞介素-1受体拮抗剂的免疫反应性则有所不同。在外根鞘中，除了对其受体有强烈染色和对拮抗剂有微弱染色外，对这四种细胞因子有弱阳性至中度染色。纤维根鞘对白细胞介素-1α和白细胞介素-6有中度免疫反应性。分布模式表明，这些细胞因子，特别是白细胞介素-1β和肿瘤坏死因子-α，可能在毛发形成中起保护作用，而所有研究的促炎细胞因子可能在分化过程中起作用。
