Lawrence W F, Fryback D G, Martin P A, Klein R, Klein B E
Department of Medicine, University of Wisconsin, Madison, USA.
J Clin Epidemiol. 1996 Nov;49(11):1239-45. doi: 10.1016/s0895-4356(96)00220-x.
We describe the relation between self-reported hypertension and measures of health-related quality of life (HRQOL) in a community-dwelling population. In a cross-sectional study, 1430 randomly selected adults, aged 45 to 89 years, were interviewed to obtain a medical history and health status measures, including the SF-36 questionnaire, the Quality of Well Being (QWB) index, and time trade-off (TTO) assessments. A total of 519 participants reported being affected by hypertension (HTN group). The HTN group, compared to the No HTN group, had significantly lower age-adjusted health status scores measured by the General Health scale of the SF-36 and by TTO, with differences between groups for each measure comprising approximately 5% of the total scale. HTNs also had a significant decline in general health status measures associated with increasing numbers of antihypertensive medications but not with specific classes of medications. We conclude that hypertension and hypertension drug therapy are associated with clinically meaningful decreases in reported health status.
我们描述了社区居住人群中自我报告的高血压与健康相关生活质量（HRQOL）测量指标之间的关系。在一项横断面研究中，对1430名年龄在45至89岁之间随机选取的成年人进行了访谈，以获取病史和健康状况测量指标，包括SF - 36问卷、幸福感质量（QWB）指数和时间权衡（TTO）评估。共有519名参与者报告患有高血压（高血压组）。与非高血压组相比，高血压组在通过SF - 36的总体健康量表和TTO测量的年龄调整后健康状况得分显著更低，每组各测量指标之间的差异约占总量表的5%。高血压患者的总体健康状况测量指标也随着抗高血压药物数量的增加而显著下降，但与特定药物类别无关。我们得出结论，高血压和高血压药物治疗与报告的健康状况在临床上有意义的下降相关。
