Batten M L, Hansen J C, Dahners L E
Department of Surgery, University of North Carolina at Chapel Hill, USA.
J Orthop Res. 1996 Sep;14(5):736-41. doi: 10.1002/jor.1100140509.
In previous studies, platelet-derived growth factor has demonstrated beneficial in vivo effects on wound healing. We report the results of two studies of platelet-derived growth factor in the rat medial collateral ligament injury model. Experimental injury sites were implanted with platelet-derived growth factor, whereas contralateral controls received only collagen. Twelve days postoperatively, the femur-medial collateral ligament-tibia complex was tested mechanically. Our first study found a marked drop in the effectiveness of platelet-derived growth factor when it was administered more than 24 hours after injury. Dose-response testing showed maximum increases in strength (90%) with 5.0 micrograms of platelet-derived growth factor, but the 1.0 microgram group showed similar strength increases, indicating a probable plateau effect in the response. These results indicate that platelet-derived growth factor has promise for healing ligaments but that it must be administered in appropriate doses soon after injury.
在先前的研究中，血小板衍生生长因子已在体内对伤口愈合显示出有益作用。我们报告了两项关于血小板衍生生长因子在大鼠内侧副韧带损伤模型中的研究结果。实验损伤部位植入了血小板衍生生长因子，而对侧对照组仅接受胶原蛋白。术后12天，对股骨-内侧副韧带-胫骨复合体进行力学测试。我们的第一项研究发现，血小板衍生生长因子在损伤后超过24小时给药时，其有效性显著下降。剂量反应测试表明，5.0微克血小板衍生生长因子可使强度最大增加90%，但1.0微克组的强度增加相似，表明反应中可能存在平台效应。这些结果表明，血小板衍生生长因子对韧带愈合有前景，但必须在损伤后不久以适当剂量给药。
