酿酒酵母第十五号染色体上VPH1 - SNF2区域的DNA序列分析。
DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.
作者信息
Chéret G, Bernardi A, Sor F
机构信息
Institut Curie, Section de Recherche, Centre Universitaire, Orsay, France.
出版信息
Yeast. 1996 Sep;12(10B Suppl):1059-64. doi: 10.1002/(SICI)1097-0061(199609)12:10B%3C1059::AID-YEA994%3E3.0.CO;2-7.
The nucleotide sequence of a 37 000 base pair region from the left arm of chromosome XV of Saccharomyces cerevisiae has been determined and analysed. This region contains 21 open reading frames (ORFs) coding for proteins of more than 100 amino acids. Six ORFs correspond to the genes PAC1, VPH1, MOD5, CAP20, ORF1 and SNF2 already described. Eight ORFs show some similarities to known genes from yeast and other organisms. They include genes coding for serine/threonine protein kinases, a multidrug resistance family homologue, a protein related to dihydrofolate reductase, a cluster of heat shock-like proteins and a gene coding for an enzyme related to protein disulfide isomerase. Finally seven ORFs do not show any similarities with a known gene. In addition we found a new ala-tRNA (UGC) gene located next to a sigma sequence.
已对酿酒酵母第十五号染色体左臂上一个37000个碱基对区域的核苷酸序列进行了测定和分析。该区域包含21个编码100多个氨基酸的蛋白质的开放阅读框（ORF）。其中六个ORF对应于已描述的基因PAC1、VPH1、MOD5、CAP20、ORF1和SNF2。八个ORF与酵母和其他生物的已知基因有一些相似性。它们包括编码丝氨酸/苏氨酸蛋白激酶的基因、一个多药耐药家族同源物、一个与二氢叶酸还原酶相关的蛋白质、一组热休克样蛋白以及一个编码与蛋白质二硫键异构酶相关的酶的基因。最后，七个ORF与已知基因没有任何相似性。此外，我们在一个sigma序列旁边发现了一个新的丙氨酸-tRNA（UGC）基因。
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