Ferrer J F, Esteban E, Dube S, Basombrio M A, Segovia A, Peralta-Ramos M, Dube D K, Sayre K, Aguayo N, Hengst J, Poiesz B J
Comparative Leukemia and Retrovirus Unit, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA.
J Infect Dis. 1996 Nov;174(5):944-53. doi: 10.1093/infdis/174.5.944.
Human T cell leukemia/lymphoma virus (HTLV-II) type II infection was detected by polymerase chain reaction or serologic analyses (or both) in 22% of 697 Indians of six different ethnic back-grounds inhabiting the Argentinean and Paraguayan Gran Chaco. None was infected with HTLV-I. The prevalence of HTLV-II increased with age (14% in those < 13 years and 23% in those > or = 13 years). HTLV-II infection was found in all 20 Gran Chaco communities studied, but marked differences (44%-4%) in the rate of infection were observed even in communities separated by only a few miles. These variations correlated closely with ethnicity. In the high-incidence communities, infection clustered within families, with evidence for both sexual and perinatal transmission, primarily via breast-feeding. By contrast, only 2% of 94 Mapuche Indians from southern Argentina were positive for HTLV-II. Analyses of pol and long terminal repeat sequences from 15 Gran Chaco HTLV-II strains indicated that they constitute a highly conserved branch of the HTLV-IIB substrain.
通过聚合酶链反应或血清学分析（或两者皆用），在居住于阿根廷和巴拉圭大查科地区的697名来自六个不同种族背景的印第安人中，检测到22%的人感染了人类T细胞白血病/淋巴瘤病毒II型（HTLV-II）。无人感染HTLV-I。HTLV-II的感染率随年龄增长而上升（13岁以下者为14%，13岁及以上者为23%）。在所研究的所有20个大查科社区中均发现了HTLV-II感染，但即便在相隔仅几英里的社区中，感染率也存在显著差异（44% - 4%）。这些差异与种族密切相关。在高感染率社区中，感染在家庭内部聚集，有证据表明存在性传播和围产期传播，主要是通过母乳喂养。相比之下，来自阿根廷南部的94名马普切印第安人中只有2%的人HTLV-II呈阳性。对来自15个大查科HTLV-II毒株的pol和长末端重复序列分析表明，它们构成了HTLV-IIB亚株的一个高度保守分支。
