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Endemic infection with HTLV-IIB in Venezuelan Indians: molecular characterization.

作者信息

Leon-Ponte M, Echeverria de Perez G, Bianco N, Hengst J, Dube S, Love J, Poiesz B J

机构信息

Institute of Immunology, Faculty of Medicine, Central University of Venezuela, Caracas.

出版信息

J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):458-64. doi: 10.1097/00042560-199804150-00011.

DOI:10.1097/00042560-199804150-00011
PMID:9562049
Abstract

The peripheral blood of 41 Yaruro and Guahibo Indians from Venezuela was examined for HTLV antibodies and DNA. Twenty-five samples (61%) were found to be infected with HTLV-IIB. The sensitivities of the serologic and DNA polymerase chain reaction (PCR) analyses were 80% and 96%, respectively. Epidemiologic studies supported both sexual and perinatal transmission of the virus. Sequence analyses of the HTLV-IIB strains from these Indians indicate that they are unique relative to HTLV-II detected in other groups of humans. HTLV-IIB-G2 isolated from a Guahibo Indian is the most divergent HTLV-IIB strain relative to the prototype HTLV-II NRA.

摘要

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