Buchet J P, Lison D, Ruggeri M, Foa V, Elia G
Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Bruxelles, Belgium.
Arch Toxicol. 1996;70(11):773-8. doi: 10.1007/s002040050339.
To assess whether regular consumption of seafood, particularly fish and shellfish, by humans may lead to an overexposure to inorganic arsenic, a well-established human carcinogen, the urinary excretion of the relevant As metabolites (Asi, inorganic form; MMA, monomethylarsonic acid; DMA, dimethylarsinic acid) was compared in groups of subjects with different seafood consumption habits and in volunteers after ingestion of a known amount of seafood arsenicals. Studies of Italian cohorts, involving five groups of +/-30 subjects with different seafood consumption habits, and balance studies in Belgian volunteers failed to show a biologically significant absorption of inorganic arsenic either present as such in the food or formed from organoarsenicals during cooking or digestion. The results suggest that the digestion of some seafood, especially mussels, may increase the urinary excretion of the dimethylated arsenic metabolite. Therefore, the biological monitoring of exposure to inorganic arsenic in an industrial context should mainly rely upon specific measurement of the unmetabolized form when recent ingestion of seafood cannot be excluded.
为评估人类经常食用海鲜，尤其是鱼类和贝类，是否会导致过度接触无机砷（一种已明确的人类致癌物），在具有不同海鲜食用习惯的受试者群体以及摄入已知量海鲜砷化物后的志愿者中，对相关砷代谢产物（Asi，无机形式；MMA，一甲基砷酸；DMA，二甲基砷酸）的尿排泄情况进行了比较。对意大利队列的研究涉及五组每组约30名具有不同海鲜食用习惯的受试者，对比利时志愿者进行的平衡研究均未显示出食物中本身存在的无机砷或烹饪或消化过程中有机砷形成的无机砷有生物学意义的吸收。结果表明，某些海鲜，特别是贻贝的消化，可能会增加二甲基化砷代谢产物的尿排泄。因此，在无法排除近期食用海鲜的情况下，工业环境中无机砷暴露的生物监测应主要依靠对未代谢形式的特定测量。
