Proesmans W, Wambeke I V, Dyck M V
Department of Paediatrics, University Hospital, University of Leuven, Belgium.
Pediatr Nephrol. 1996 Oct;10(5):587-9. doi: 10.1007/s004670050166.
The effect of enalapril on urinary protein excretion and renal function was studied in six paediatric patients with various renal diseases causing nephroticrange proteinuria. In three younger children (aged 7-9 years) with steroid-resistant nephrotic syndrome, enalapril at a dose of 0.5 mg/kg per day given for 24 months yielded a temporary reduction of proteinuria in one child, a moderate and steady decrease in another and a complete disappearance of proteinuria in the third. Three adolescents, aged 17 years, took enalapril for 24 months at a dose of 20 mg/day. We observed no effect on proteiuria in one patient with Alport syndrome, a complete disappearance of urinary protein in one patient with membranoproliferative glomerulonephritis and a moderate decrease in the third patient who had idiopathic steroid-resistant nephrotic syndrome. Enalapril therapy resulted in an important reduction of proteinuria in two patients and a moderate decrease in three others. However this therapy was accompanied by a fall in glomerular filtration in all subjects, which was very marked in two patients. This fall in glomerular filtration may, however, simply reflect the natural course of the disease.
在六名患有各种导致肾病范围蛋白尿的肾脏疾病的儿科患者中，研究了依那普利对尿蛋白排泄和肾功能的影响。在三名患有激素抵抗性肾病综合征的年幼儿童（7至9岁）中，每天给予0.5mg/kg剂量的依那普利，持续24个月，其中一名儿童蛋白尿暂时减少，另一名儿童蛋白尿适度且稳定地减少，第三名儿童蛋白尿完全消失。三名17岁的青少年每天服用20mg依那普利，持续24个月。我们观察到，一名患有Alport综合征的患者蛋白尿无变化，一名患有膜增生性肾小球肾炎的患者尿蛋白完全消失，第三名患有特发性激素抵抗性肾病综合征的患者蛋白尿适度减少。依那普利治疗使两名患者的蛋白尿显著减少，另外三名患者的蛋白尿适度减少。然而，这种治疗伴随着所有受试者肾小球滤过率下降，其中两名患者下降非常明显。然而，这种肾小球滤过率下降可能仅仅反映了疾病的自然进程。
