Sorsa M, Osterman-Golkar S, Peltonen K, Saarikoski S T, Sram R
Ministry of Education, Helsinki, Finland.
Toxicology. 1996 Oct 28;113(1-3):77-83. doi: 10.1016/0300-483x(96)03430-0.
Occupational exposure levels to 1,3-butadiene (BD) are variable but generally below 1 ppm in the European process industry. A preliminary analysis showed that hemoglobin adduct levels of butadiene monoxide (BMO) were increased among the worker groups with higher potential exposure to BD (process work, bomb voiding, repair duties) than among less exposed workers in maintenance and laboratory or control persons. In the same workers no exposure related effects were seen in the cytogenetic parameters studied, i.e. chromosomal aberrations, sister chromatid exchanges or micronuclei in peripheral blood lymphocytes. However, the glutathione-S-transferase polymorphism in the T1 gene might play a role in determining interindividual sensitivity to BD-induced chromosomal aberrations. Chromosomal aberrations (gaps excluded) were significantly (P < 0.05) increased among the workers lacking the GSTT1 gene as compared to the BD workers with the gene, while the other polymorphic GSTM1 gene showed no association with the cytogenetic parameters. More work needs to be done to study the adducts by other active BD metabolites than BMO and the role of the genetic polymorphisms controlling the variability of individual responses.
在欧洲加工行业中，职业接触1,3 - 丁二烯（BD）的水平各不相同，但一般低于1 ppm。初步分析表明，与维护、实验室或控制人员等接触较少的工人相比，在有可能较高接触BD的工人群体（工艺工作、炸弹排空、维修职责）中，丁二烯 monoxide（BMO）的血红蛋白加合物水平有所升高。在同一批工人中，在所研究的细胞遗传学参数方面，即外周血淋巴细胞中的染色体畸变、姐妹染色单体交换或微核，未观察到与接触相关的影响。然而，T1基因中的谷胱甘肽 - S - 转移酶多态性可能在决定个体对BD诱导的染色体畸变的敏感性方面发挥作用。与具有该基因的BD工人相比，缺乏GSTT1基因的工人中染色体畸变（不包括间隙）显著（P < 0.05）增加，而另一个多态性GSTM1基因与细胞遗传学参数无关联。需要开展更多工作来研究除BMO之外的其他活性BD代谢物的加合物以及控制个体反应变异性的基因多态性的作用。
