Hoppichler F, Lechleitner M, Traweger C, Schett G, Dzien A, Sturm W, Xu Q
Department of Internal Medicine, University of Innsbruck, Austria.
Atherosclerosis. 1996 Oct 25;126(2):333-8. doi: 10.1016/0021-9150(96)05931-x.
Accumulating evidence indicates the involvement of heat shock proteins (hsp), a family of stress-inducible proteins, in atherosclerosis. For carotid atherosclerosis an association with an increase in hsp65 antibodies has been demonstrated. To investigate whether such antibodies are also associated with coronary heart disease (CHD) and acute myocardial infarction (MI), an age- and sex-matched study with patients suffering from CHD (n = 114) and MI (n = 89) and healthy controls (n = 76) was performed. All study participants (n = 279) were consecutively recruited according to typical diagnostic criteria. Determination of antibody titres to hsp65 was performed by an enzyme-linked immunosorbent assay (ELISA). Hsp65 antibody titres in CHD showed a significant increase compared to the healthy control group (P = 0.029), however, hsp65 antibody titres were found to be significantly lower in acute MI, compared to CHD (P = 0.005). Alteration in hsp65 antibody titres showed no correlation to established cardiovascular risk factors, e.g. serum total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood pressure, smoking, alcohol intake and body weight. In conclusion, serum concentrations of hsp65 antibodies were elevated independently in coronary heart diseases and declined in patients with acute myocardial infarction, indicating a possible involvement of the antibodies in the pathogenesis of this disease.
越来越多的证据表明，热休克蛋白（hsp）这一应激诱导蛋白家族参与了动脉粥样硬化的发生。对于颈动脉粥样硬化，已证实其与hsp65抗体增加有关。为了研究此类抗体是否也与冠心病（CHD）和急性心肌梗死（MI）相关，我们对患有CHD（n = 114）、MI（n = 89）的患者以及健康对照者（n = 76）进行了一项年龄和性别匹配的研究。所有研究参与者（n = 279）均根据典型诊断标准连续招募。采用酶联免疫吸附测定（ELISA）法测定hsp65抗体滴度。与健康对照组相比，CHD患者的hsp65抗体滴度显著升高（P = 0.029），然而，与CHD相比，急性MI患者的hsp65抗体滴度显著降低（P = 0.005）。hsp65抗体滴度的变化与已确定的心血管危险因素，如血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、血压、吸烟、饮酒和体重，均无相关性。总之，冠心病患者血清中hsp65抗体浓度独立升高，而急性心肌梗死患者血清中hsp65抗体浓度降低，这表明该抗体可能参与了这种疾病的发病机制。
