Simón C, Mercader A, Frances A, Gimeno M J, Polan M L, Remohí J, Pellicer A
Instituto Valenciano de Infertilidad, Valencia University, Spain.
J Reprod Immunol. 1996 Oct;31(3):165-84. doi: 10.1016/0165-0378(96)00982-5.
We have investigated serum and intracavitary levels of IL-1 alpha, IL-1 beta and IL-1ra from agonadal women undergoing mock cycles (n = 20) of oocyte donation as a clinical model of controlled hormonal stimulation. Further, we compared the intracavitary IL-1 alpha, IL-1 beta and IL-1ra levels in the microenvironment of the human embryo at the apposition phase, day 5 after progesterone (P) administration using two different clinical models: oocyte donation (n = 20) which provides physiological steroid levels and a higher implantation rate per embryo, and in vitro fertilization (n = 6) with supraphysiological hormonal levels and a lower implantation rate.
我们以接受模拟卵母细胞捐赠周期（n = 20）的无性腺女性作为控制性激素刺激的临床模型，研究了白细胞介素-1α（IL-1α）、白细胞介素-1β（IL-1β）和白细胞介素-1受体拮抗剂（IL-1ra）的血清和腔内水平。此外，我们使用两种不同的临床模型，比较了在给予孕酮（P）后第5天的附着期人类胚胎微环境中的腔内IL-1α、IL-1β和IL-1ra水平：卵母细胞捐赠（n = 20），其提供生理类固醇水平且每个胚胎的着床率较高；体外受精（n = 6），其具有超生理激素水平且着床率较低。
