Rahhal F M, Siegel L M, Russak V, Wiley C A, Tedder D G, Weinberg A, Rickman L, Freeman W R
Department of Ophthalmology, University of California, San Diego School of Medicine, La Jolla, USA.
Arch Ophthalmol. 1996 Nov;114(11):1416-9. doi: 10.1001/archopht.1996.01100140616019.
The acute retinal necrosis syndrome is a rapidly progressive and potentially devastating disease. A case of acute retinal necrosis developed in an immunocompetent man, Presumably due to the stress, trauma, or immunomodulation related to a craniotomy for a parasellar craniopharyngioma. Vitrectomy and endoretinal biopsy were performed. Polymerase chain reaction studies of the vitreous revealed herpes simplex virus type 2 as the cause, which has not been previously well documented. Results of cerebrospinal fluid antibody studies were also consistent with the diagnosis. Results of cytology and histopathologic examination demonstrated extensive retinal destruction and mononuclear cell infiltration. Sloughing of the inner retina was evidenced by the presence of retinal vascular remnants in the vitreous cytology specimen. As is characteristic of this disease, the visual outcome of this patient was poor.
急性视网膜坏死综合征是一种迅速进展且可能具有毁灭性的疾病。一名免疫功能正常的男性发生了急性视网膜坏死，推测是由于与鞍旁颅咽管瘤开颅手术相关的应激、创伤或免疫调节所致。进行了玻璃体切除术和视网膜内活检。玻璃体的聚合酶链反应研究显示病因是2型单纯疱疹病毒，此前尚无充分记录。脑脊液抗体研究结果也与诊断相符。细胞学和组织病理学检查结果显示视网膜广泛破坏和单核细胞浸润。玻璃体细胞学标本中存在视网膜血管残余物，证明视网膜内层有脱落。正如该疾病的特征那样，该患者的视觉预后很差。
