健康孕期中活化的细胞免疫及血清色氨酸水平降低

Activated cellular immunity and decreased serum tryptophan in healthy pregnancy.

作者信息

Fuchs D, Schröcksnadel H, Baier-Bitterlich G, Dapunt O, Wachter H

机构信息

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

出版信息

Adv Exp Med Biol. 1996;398:149-53. doi: 10.1007/978-1-4613-0381-7_24.

DOI:10.1007/978-1-4613-0381-7_24

PMID:8906258

Abstract

We analyzed plasma samples from 45 randomly selected healthy pregnant women and from 20 healthy nonpregnant female controls of corresponding age. Tryptophan and kynurenine concentrations were measured by reverse-phase high performance liquid chromatography. The kynurenine per tryptophan ratio was calculated to allow a more accurate estimate of tryptophan degradation. In addition, neopterin was measured by radioimmunoassay. There were significantly lower tryptophan concentrations in pregnant women compared to nonpregnant controls. Kynurenine per tryptophan ratios were increased in pregnant women in the 3rd trimester. Significant correlations existed between neopterin increase and tryptophan decrease as well as kynurenine increase and tryptophan decrease. Also significant correlations between week of pregnancy and lower tryptophan and higher kynurenine per tryptophan ratio were found (p < 0.01). From our data, cellular immune activation is likely to be the cause of enhanced tryptophan degradation during pregnancy.

摘要

我们分析了45名随机挑选的健康孕妇以及20名年龄相仿的健康非孕女性对照者的血浆样本。采用反相高效液相色谱法测定色氨酸和犬尿氨酸浓度。计算犬尿氨酸与色氨酸的比值，以便更准确地估计色氨酸的降解情况。此外，采用放射免疫分析法测定新蝶呤。与非孕对照者相比，孕妇的色氨酸浓度显著降低。孕晚期孕妇的犬尿氨酸与色氨酸比值升高。新蝶呤增加与色氨酸减少以及犬尿氨酸增加与色氨酸减少之间存在显著相关性。同时还发现妊娠周数与色氨酸降低以及犬尿氨酸与色氨酸比值升高之间存在显著相关性（p < 0.01）。根据我们的数据，细胞免疫激活可能是孕期色氨酸降解增强的原因。