de Carvalho Jozélio Freire, Skare Thelma L
Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis (NUPEN), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.
Rheumatology Unit, Hospital Evangélico Mackenzie, Curitiba, PR, Brazil.
Mediterr J Rheumatol. 2025 Mar 31;36(1):1-7. doi: 10.31138/mjr.220424.pam. eCollection 2025 Mar.
Fibromyalgia (FM) occurs frequently in women of childbearing age. These patients may become pregnant, and it is essential to know the influence of pregnancy on this disease.
To review the studies of pregnancy in FM.
To systematically search for articles on pregnancy and FM between 1966 and April 2024. No language limitation was used. Scielo, PubMed, and Embase databases were analysed.
Twelve articles with 8,833 patients were found. Patients' ages varied from > 18 to 65 years old. FM patients had a lower number of children and more nulliparity than controls. Studies that analysed FM symptoms during pregnancy found symptom worsening, mainly pain, anxiety, depression, and gestational diabetes, were found to be more common than in controls in 2 papers. Regarding neonatal outcomes, only four studies evaluated these data: two of them found that FM had no adverse effect on the neonate's health. In contrast, the other two found that these babies were more likely to be premature, to have intrauterine growth restriction, and to have low Apgar.
This systematic review demonstrates that pregnancy in FM usually has a bad prognosis since obstetric and FM outcomes are worse during this period. Results of repercussions on the offspring are controversial.
纤维肌痛（FM）在育龄女性中频繁出现。这些患者可能会怀孕，了解怀孕对这种疾病的影响至关重要。
回顾关于FM患者怀孕情况的研究。
系统检索1966年至2024年4月期间关于怀孕与FM的文章。不设语言限制。对Scielo、PubMed和Embase数据库进行分析。
共找到12篇文章，涉及8833例患者。患者年龄从大于18岁至65岁不等。与对照组相比，FM患者的子女数量较少且初产情况较多。有2篇论文对孕期FM症状进行分析，发现症状恶化，主要是疼痛、焦虑、抑郁和妊娠期糖尿病，在FM患者中比对照组更常见。关于新生儿结局，仅有4项研究评估了这些数据：其中2项研究发现FM对新生儿健康无不良影响。相比之下，另外2项研究发现这些婴儿更有可能早产、出现宫内生长受限以及阿氏评分较低。
本系统评价表明，FM患者怀孕通常预后不佳，因为在此期间产科和FM结局更差。对后代的影响结果存在争议。
