Vobecký M, Babický A, Lener J, Svandová E
Academy of Sciences of Czech Republic, Institute of Analytical Chemistry, Praha, Czech Republic.
Biol Trace Elem Res. 1996 Sep;54(3):207-12. doi: 10.1007/BF02784432.
In experiments with rats, we have found that at enhanced intake of bromide, bromine does not replace chlorine in the thyroid; it replaces iodine. Under our experimental conditions, more than one-third of the iodine content in the thyroid was replaced by bromine. In the thyroid, bromine probably remained in the form of bromide and, in proportional to its increased concentration, the production of iodinated thyronines decreased, with the sum of the iodine and bromine concentrations being constant at the value of 20.51 +/- 1.16 mumol/g dry wt of the thyroid. In contrast to other organs, the biological behavior of bromine in the thyroid is not similar to the biological behavior of chlorine but resembles more that of iodine.
在对大鼠的实验中，我们发现，当溴化物摄入量增加时，溴在甲状腺中不会取代氯，而是取代碘。在我们的实验条件下，甲状腺中超过三分之一的碘含量被溴取代。在甲状腺中，溴可能以溴化物的形式存在，并且随着其浓度的增加，碘化甲状腺原氨酸的生成减少，甲状腺干重中碘和溴的浓度总和恒定在20.51±1.16μmol/g。与其他器官不同，溴在甲状腺中的生物学行为与氯的生物学行为不同，而更类似于碘的生物学行为。
