肾病综合征患者血清IgG亚类水平的不对称降低。
Asymmetric depression in the serum level of IgG subclasses in patients with nephrotic syndrome.
作者信息
Shakib F, Hardwicke J, Stanworth D R, White R H
出版信息
Clin Exp Immunol. 1977 Jun;28(3):506-11.
Abstract
Thirty-three nephrotic patients were studied for IgG-subclass levels in matched pairs of serum and urinary specimens. Levels in the serum were compared with those found in the sera of non-nephrotic control children and normal adults. Results have shown an asymmetric depression in the serum level of certain IgG subclasses in some patients with minimal-change nephrotic syndrome, focal glomerulosclerosis, and proliferative glomerulonephritis, indicating that the urinary loss of IgG alone cannot account for the low blood levels of this immunoglobulin class in these conditions.
摘要
对33例肾病患者的配对血清和尿液标本中的IgG亚类水平进行了研究。将血清中的水平与非肾病对照儿童和正常成年人血清中的水平进行了比较。结果显示，一些患有微小病变性肾病综合征、局灶性肾小球硬化症和增殖性肾小球肾炎的患者血清中某些IgG亚类水平呈不对称性降低，这表明在这些情况下，仅IgG的尿流失不能解释该免疫球蛋白类别的低血水平。
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