霍奇金病患者淋巴细胞表面的铁蛋白。一种可能被左旋咪唑去除的阻断物质。
Ferritin on the surface of lymphocytes in Hodgkin's disease patients. A possible blocking substance removed by levamisole.
作者信息
Moroz C, Lahat N, Biniaminov M, Ramot B
出版信息
Clin Exp Immunol. 1977 Jul;29(1):30-5.
Abstract
Enzymatic radioiodination of surface proteins of Hodgkin's disease peripheral blood mononuclear cells revealed the presence of a blocking protein on their surface. This protein shed into the medium after incubation with levamisole, which resulted in the unmasking of surface proteins similar to those on normal monunuclear cells. The blocking substance was identified. It reacted with anti-human spleen ferritin. It had no detectable iron and dissociated into monomeric subunits of 18,000 mol. wt. by reduction and alkylation, and therefore it is most probably apoferritin rather than ferritin.
摘要
霍奇金病外周血单核细胞表面蛋白的酶促放射性碘化显示其表面存在一种封闭蛋白。该蛋白在与左旋咪唑孵育后释放到培养基中，这导致类似于正常单核细胞表面蛋白的暴露。封闭物质得到了鉴定。它与抗人脾脏铁蛋白发生反应。它不含可检测到的铁，通过还原和烷基化可解离成分子量为18,000的单体亚基，因此它很可能是脱铁铁蛋白而不是铁蛋白。
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