Payne S V, Newell D G, Jones D B, Wright D H
Am J Pathol. 1980 Jul;100(1):7-24.
Autologous T lymphocytes form broad, unspecialized, noninvaginating contacts with Reed-Sternberg cells in vitro. These differ from contacts between cytotoxic lymphocytes and their targets and from the uropodal type of lymphocyte adherence described in many antigen- (or mitogen-) dependent systems but show some resemblance to antigen-independent lymphocyte/macrophage contacts. Adherence is not confined to a specific T-cell subset; most adherent cells are negative for ANAE, Fc gamma, and Fc mu receptors. A minority have Fc mu or Fc gamma receptors or show ANAE staining. Adherence is dependent on divalent cations and intact surface proteins but is independent of temperature, cell metabolism, and intact microtubules and does not appear to be mediated by Fc gamma receptors or IgG. These characteristics distinguish it from immune T-cell/target-cell binding and from antigen-independent T-cell/macrophage or T-cell/B-lymphoblast binding. Contrary to previous suggestions, this interaction is not related to a cytotoxic attack. The lack of similarities with other lymphocyte adherence systems leads the authors to suggest that a unique receptor system is involved.
在体外，自体T淋巴细胞与里德-施特恩伯格细胞形成广泛、非特异性、无内陷的接触。这些接触不同于细胞毒性淋巴细胞与其靶细胞之间的接触，也不同于许多抗原（或丝裂原）依赖性系统中描述的尾足型淋巴细胞黏附，但与抗原非依赖性淋巴细胞/巨噬细胞接触有一些相似之处。黏附不限于特定的T细胞亚群；大多数黏附细胞的ANAE、Fcγ和Fcμ受体呈阴性。少数细胞具有Fcμ或Fcγ受体或显示ANAE染色。黏附依赖于二价阳离子和完整的表面蛋白，但与温度、细胞代谢和完整的微管无关，似乎也不是由Fcγ受体或IgG介导的。这些特征将其与免疫T细胞/靶细胞结合以及抗原非依赖性T细胞/巨噬细胞或T细胞/B淋巴母细胞结合区分开来。与先前的观点相反，这种相互作用与细胞毒性攻击无关。与其他淋巴细胞黏附系统缺乏相似性，使得作者认为涉及一种独特的受体系统。
