Low P S, Heng C K, Saha N, Tay J S
Department of Paediatrics, National University of Singapore, Singapore.
Pediatr Res. 1996 Nov;40(5):718-22. doi: 10.1203/00006450-199611000-00011.
Lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for atherosclerosis. Studies have also shown that there are racial differences in the Lp(a) profile. The multiracial population of Singapore has demonstrated a differential prevalence of coronary artery disease, which is concordant with the plasma Lp(a) profile in the adult populations of Singapore. The level of Lp(a) is under strict genetic control, and its plasma concentration is determined significantly by inheritance. Expression of the racial profile of Lp(a) at birth was studied in the cord blood of 542 male and 468 female newborns from three ethnic groups of Singapore using the sandwich-ELISA. The Lp(a) levels were then related to the coronary risk levels of their respective adult populations. Lp(a) levels in Singapore newborns were found to be independent of the infant's birth weight and sex but were significantly influenced by race. Indian newborns had significantly higher plasma levels of Lp(a). Chinese newborns had the lowest Lp(a) levels at birth. The ranking of Lp(a) levels at birth was concordant with the relative coronary mortality rates for the respective adult populations of Singapore. Racial differences in plasma Lp(a) levels are present and expressed at birth.
脂蛋白(a)[Lp(a)]被认为是动脉粥样硬化的独立危险因素。研究还表明，Lp(a)水平存在种族差异。新加坡的多民族人口已显示出冠心病患病率的差异，这与新加坡成年人口的血浆Lp(a)水平相符。Lp(a)水平受严格的基因控制，其血浆浓度很大程度上由遗传决定。采用夹心酶联免疫吸附测定法（sandwich-ELISA），对来自新加坡三个种族的542名男婴和468名女婴的脐带血进行研究，以探讨出生时Lp(a)的种族特征表达情况。然后将Lp(a)水平与其各自成年人群的冠心病风险水平相关联。研究发现，新加坡新生儿的Lp(a)水平与婴儿出生体重和性别无关，但受种族影响显著。印度新生儿的血浆Lp(a)水平显著更高。中国新生儿出生时的Lp(a)水平最低。出生时Lp(a)水平的排序与新加坡各自成年人群的相对冠心病死亡率相符。血浆Lp(a)水平的种族差异在出生时就已存在并表现出来。
