• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases.

作者信息

Harris J M, Gonzalez-Bello C, Kleanthous C, Hawkins A R, Coggins J R, Abell C

机构信息

Cambridge Centre for Molecular Recognition, University Chemical Laboratory, U.K.

出版信息

Biochem J. 1996 Oct 15;319 ( Pt 2)(Pt 2):333-6. doi: 10.1042/bj3190333.

DOI:10.1042/bj3190333
PMID:8912664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1217773/
Abstract
摘要

相似文献

1
Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases.动力学同位素研究提供的证据表明，II型脱氢奎尼酸酶的作用机制中有烯醇负离子中间体。
Biochem J. 1996 Oct 15;319 ( Pt 2)(Pt 2):333-6. doi: 10.1042/bj3190333.
2
[Calculation of the error in the variable Hill coefficient used for analysis of the unusual kinetic behavior of "biosynthetic" L-threonine dehydratase].[用于分析“生物合成”L-苏氨酸脱水酶异常动力学行为的可变希尔系数误差计算]
Dokl Akad Nauk SSSR. 1972 Apr 21;203(6):1414-7.
3
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases.
Org Biomol Chem. 2004 Jun 7;2(11):1592-6. doi: 10.1039/b404535a. Epub 2004 May 6.
4
The mechanism of action of 5'-adenylic acid-activated threonine dehydrase. IV. Characterization of kinetic effect of adenosine monophosphate.5'-腺苷酸激活的苏氨酸脱水酶的作用机制。IV. 一磷酸腺苷动力学效应的表征
J Biol Chem. 1973 Dec 10;248(23):8189-99.
5
Circular dichroism of biodegradative threnonine deaminase.
Biochem Biophys Res Commun. 1967 Oct 26;29(2):184-8. doi: 10.1016/0006-291x(67)90584-0.
6
3-Dehydroquinate dehydratase from Escherichia coli.来自大肠杆菌的3-脱氢奎尼酸脱水酶。
Methods Enzymol. 1987;142:320-4.
7
The use of electrospray mass spectrometry to identify an essential arginine residue in type II dehydroquinases.使用电喷雾质谱法鉴定II型脱氢奎尼酸酶中的一个必需精氨酸残基。
FEBS Lett. 1995 Feb 20;360(1):93-6. doi: 10.1016/0014-5793(95)00083-l.
8
Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine.来自大肠杆菌的二氢二吡啶甲酸合酶：动力学机制的pH依赖性变化以及L-赖氨酸的变构抑制动力学机制。
Biochemistry. 1997 Feb 18;36(7):1730-9. doi: 10.1021/bi962264x.
9
Coenzymatic activity of homologues of pyridoxal phosphate.磷酸吡哆醛同系物的辅酶活性。
Proc Natl Acad Sci U S A. 1967 Jun;57(6):1692-9. doi: 10.1073/pnas.57.6.1692.
10
Vinyl fluoride as an isoelectronic replacement for an enolate anion: inhibition of type II dehydroquinases.氟乙烯作为烯醇负离子的等电子替代物：对II型脱氢奎尼酸酶的抑制作用
Chem Commun (Camb). 2002 Sep 7(17):1886-7. doi: 10.1039/b205105m.

引用本文的文献

1
An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway.细菌莽草酸途径中酶的进化保守性与成药性分析
Antibiotics (Basel). 2022 May 17;11(5):675. doi: 10.3390/antibiotics11050675.
2
Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs.莽草酸途径酶作为抗结核药物合理设计的靶点。
Molecules. 2020 Mar 11;25(6):1259. doi: 10.3390/molecules25061259.
3
QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes.QM/MM 模拟确定了 II 型脱氢酶之间催化活性差异的决定因素。
Org Biomol Chem. 2018 Jun 20;16(24):4443-4455. doi: 10.1039/c8ob00066b.
4
Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway.解析莽草酸途径中微生物3-脱氢奎尼酸脱水酶的动力学多样性。
AMB Express. 2015 Feb 1;5:7. doi: 10.1186/s13568-014-0087-y. eCollection 2015.
5
Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.艰难梭菌脱氢奎尼酸脱水酶选择性抑制剂的发现。
PLoS One. 2014 Feb 21;9(2):e89356. doi: 10.1371/journal.pone.0089356. eCollection 2014.
6
Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation.Ⅰ型脱水奎宁酸脱氨酶与奎宁酸和莽草酸复合物的晶体结构提示了席夫碱形成的新机制。
Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31.
7
Crystal structure of a type II dehydroquinate dehydratase-like protein from Bifidobacterium longum.长双歧杆菌II型脱氢奎尼酸脱水酶样蛋白的晶体结构
J Struct Funct Genomics. 2013 Mar;14(1):25-30. doi: 10.1007/s10969-013-9149-7. Epub 2013 Mar 29.
8
Reassessing the type I dehydroquinate dehydratase catalytic triad: kinetic and structural studies of Glu86 mutants.重新评估 I 型脱氢奎宁酸脱水酶的催化三联体：Glu86 突变体的动力学和结构研究。
Protein Sci. 2013 Apr;22(4):418-24. doi: 10.1002/pro.2218. Epub 2013 Feb 11.
9
A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding.I 型脱水奎宁酸脱水酶中的保守表面环定位活性位点精氨酸并在底物结合中发挥作用。
Biochemistry. 2011 Mar 29;50(12):2357-63. doi: 10.1021/bi102020s. Epub 2011 Feb 21.
10
New molecular scaffolds for the design of Mycobacterium tuberculosis type II dehydroquinase inhibitors identified using ligand and receptor based virtual screening.基于配体和受体的虚拟筛选技术鉴定新型结核分枝杆菌 II 型脱氢奎宁酸抑制剂的分子骨架。
J Mol Model. 2010 Apr;16(4):693-712. doi: 10.1007/s00894-009-0595-x. Epub 2009 Oct 9.

本文引用的文献

1
Crystallization of a type II dehydroquinase from Mycobacterium tuberculosis.
J Mol Biol. 1994 Aug 19;241(3):488-91. doi: 10.1006/jmbi.1994.1524.
2
The use of electrospray mass spectrometry to identify an essential arginine residue in type II dehydroquinases.使用电喷雾质谱法鉴定II型脱氢奎尼酸酶中的一个必需精氨酸残基。
FEBS Lett. 1995 Feb 20;360(1):93-6. doi: 10.1016/0014-5793(95)00083-l.
3
Buffers of constant ionic strength for studying pH-dependent processes.用于研究pH依赖性过程的恒定离子强度缓冲液。
Methods Enzymol. 1982;87:405-26. doi: 10.1016/s0076-6879(82)87025-0.
4
Solvent isotope effects of enzyme systems.酶系统的溶剂同位素效应。
Methods Enzymol. 1982;87:551-606.
5
Purification and characterization of 3-dehydroquinase from Escherichia coli.大肠杆菌3-脱氢奎尼酸酶的纯化与特性分析
Biochem J. 1986 Nov 1;239(3):699-704. doi: 10.1042/bj2390699.
6
Gene organization and regulation in the qa (quinic acid) gene cluster of Neurospora crassa.粗糙脉孢菌喹啉酸（qa）基因簇中的基因组织与调控
Microbiol Rev. 1985 Sep;49(3):338-58. doi: 10.1128/mr.49.3.338-358.1985.
7
The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.结核分枝杆菌莽草酸途径基因：生物合成和分解代谢3-脱氢奎尼酸酶之间的进化关系。
Mol Gen Genet. 1991 Sep;228(3):385-92. doi: 10.1007/BF00260631.
8
Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases.两种生物合成3-脱氢奎尼酸酶活性位点赖氨酸残基的鉴定
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):1-6. doi: 10.1042/bj2750001.
9
A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes.两类不同脱氢奎尼酸酶的酶学性质与生物物理性质比较
Biochem J. 1992 Mar 15;282 ( Pt 3)(Pt 3):687-95. doi: 10.1042/bj2820687.
10
Purification and characterization of a dual function 3-dehydroquinate dehydratase from Amycolatopsis methanolica.来自甲醇拟无枝酸菌的双功能3-脱氢奎尼酸脱水酶的纯化与特性分析
J Gen Microbiol. 1992 Nov;138(11):2449-57. doi: 10.1099/00221287-138-11-2449.