Kauppi M, Pukkala E, Isomäki H
Rheumatism Foundation Hospital, Heinola, Finland.
Clin Exp Rheumatol. 1996 Sep-Oct;14(5):551-3.
Aspirin (ASA) and also nonsteroidal anti-inflammatory drug (NSAID) use has been associated with a low incidence of colorectal cancer. The incidence of colorectal cancer in a cohort of patients with rheumatoid arthritis (RA) is reported here.
Cancer incidence was studied in a cohort of 9469 persons hospitalized for RA during 1970-1991 in Finland. The follow-up time was about 65,400 person-years.
The incidence of colon cancer was significantly lower than in the general population [standardized incidence ratio (SIR) 0.57; 95% confidence interval (CI) 0.33-0.93], and the combined SIR for colorectal cancer was 0.62 (95% CI 0.42-0.88), while the combined incidence of all malignancies (SIR 1.16; 95% CI 1.07-1.26) was higher in RA patients than in the general population.
Chronic use of NSAIDs or ASA, including antiinflammatory doses, is probably the main explanation for the low incidence of colorectal cancer in RA patients.
阿司匹林（ASA）以及非甾体抗炎药（NSAID）的使用与结直肠癌的低发病率相关。本文报告了一组类风湿关节炎（RA）患者的结直肠癌发病率。
对1970年至1991年期间在芬兰因RA住院的9469人队列中的癌症发病率进行了研究。随访时间约为65400人年。
结肠癌发病率显著低于普通人群[标准化发病率比（SIR）0.57；95%置信区间（CI）0.33 - 0.93]，结直肠癌的合并SIR为0.62（95%CI 0.42 - 0.88），而RA患者中所有恶性肿瘤的合并发病率（SIR 1.16；95%CI 1.07 - 1.26）高于普通人群。
长期使用NSAIDs或ASA，包括抗炎剂量，可能是RA患者结直肠癌发病率低的主要原因。
