Koller A, Heitman J, Hall M N
Department of Biochemistry, University of Basel, Switzerland.
Genetics. 1996 Nov;144(3):957-66. doi: 10.1093/genetics/144.3.957.
In meiosis I, homologous chromosomes pair, recombine and segregate to opposite poles. These events and subsequent meiosis II ensure that each of the four meiotic products has one complete set of chromosomes. In this study, the meiotic pairing and segregation of a trisomic chromosome in a diploid (2n + 1) yeast strain was examined. We find that trivalent pairing and segregation is the favored arrangement. However, insertions near the centromere in one of the trisomic chromosomes leads to preferential pairing and segregation of the "like" centromeres of the remaining two chromosomes, suggesting that bivalent-univalent pairing and segregation is favored for this region.
在减数分裂I中，同源染色体配对、重组并分离到相反的两极。这些事件以及随后的减数分裂II确保四个减数分裂产物中的每一个都有一套完整的染色体。在本研究中，检测了二倍体（2n + 1）酵母菌株中一条三体染色体的减数分裂配对和分离情况。我们发现三价配对和分离是有利的排列方式。然而，三体染色体之一的着丝粒附近的插入导致其余两条染色体的“相似”着丝粒优先配对和分离，这表明该区域有利于二价-单价配对和分离。
