Lu Yingzhi, Qi Xiaoying, Zhao Qi, Chen Yifan, Liu Yanjiang, Li Xiawen, Yu Yuguo, Zhou Chengling
School of Psychology, Shanghai University of Sport, Shanghai, 200438 China.
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Life Science and Human Phenome Institute, Institutes of Brain Science, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433 China.
Cogn Neurodyn. 2021 Feb;15(1):27-42. doi: 10.1007/s11571-020-09647-w. Epub 2020 Nov 2.
Exercise interventions have been considered to be an effective treatment for drug addiction. However, there is little dirct evidence that exercise affects brain activity in individuals afftected by drug addiction. Therefore, the aim of the present study was to investigate the effects of different exercise programs on detoxification. Cognitive recovery with 64-channel electroencephalography (EEG) recordings was obtained before and after three months of daily aerobic and anaerobic exercise. A total of 63 subjects with methamphetamine addiction were recruited and randomly divided into three groups for cognitive study in four behavioral states: an anaerobic resistance treatment group, an aerobic cycling treatment group and a control group. In addition, four behavioral states were examined: eyes-closed and eyes-open resting states, and exploratory behavior states following either drug- or neutral-cue exposure. Over a 12-week period,the alpha block ratio in the control group showed a slight decrease, while clear increases were observed in the resistance exercise and cycling treatment groups, particularly under the frontal and temporal regions in the eyes-open and drug-cue conditions. The major EEG activity frequency in the resistance treatment group during the drug-cue behavior task decreased compared with the frequencies of the cycling exercise and control groups. Meanwhile, the power of higher brain rhythms in the resistance treatment group was increased. Finally, the brain alpha wave left-lateralization index from EEG recording sites, F1-F2, in the resistance and cycling treatment groups under the eyes-closed condition positively decreased, while the control groups only showed slight decreases. Taken together, these results suggest that different types of exercise may induce distince and different positive therapeutic effects to facilitate detoxification.
运动干预已被认为是治疗药物成瘾的有效方法。然而，几乎没有直接证据表明运动对药物成瘾者的大脑活动有影响。因此，本研究的目的是调查不同运动方案对戒毒的影响。在进行为期三个月的每日有氧运动和无氧运动前后，通过64通道脑电图（EEG）记录获得认知恢复情况。共招募了63名甲基苯丙胺成瘾者，并将他们随机分为三组，在四种行为状态下进行认知研究：无氧抗阻治疗组、有氧骑行治疗组和对照组。此外，还检查了四种行为状态：闭眼和睁眼静息状态，以及药物提示或中性提示暴露后的探索行为状态。在12周的时间里，对照组的α波阻断率略有下降，而抗阻运动组和骑行治疗组则明显增加，特别是在睁眼和药物提示条件下的额叶和颞叶区域。与骑行运动组和对照组相比，抗阻治疗组在药物提示行为任务期间的主要脑电图活动频率降低。同时，抗阻治疗组的大脑高级节律功率增加。最后，在闭眼条件下，抗阻治疗组和骑行治疗组脑电图记录部位F1 - F2的大脑α波左侧化指数呈正向下降，而对照组仅略有下降。综上所述，这些结果表明不同类型的运动可能会诱导出不同且积极的治疗效果，以促进戒毒。
