一氧化氮在猫的运动适应性控制中起关键作用。
Nitric oxide plays a key role in adaptive control of locomotion in cat.
作者信息
Yanagihara D, Kondo I
机构信息
Division of Neuromuscular Skills, Faculty of Health and Sport Sciences, Osaka University, Japan.
出版信息
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13292-7. doi: 10.1073/pnas.93.23.13292.
Abstract
Diverse roles in cellular functions have been ascribed to nitric oxide (NO), and its involvement in induction of long-term depression in cerebellar Purkinje cells has been demonstrated. Manipulations of NO concentration or its synthesis in cerebellar tissues therefore provide a means for investigating roles of NO in cerebellar functions at both cellular and behavioral levels. We tested adaptive control of locomotion to perturbation in cats, and found that this form of motor learning was abolished by application of either an inhibitor of NO synthase or a scavenger of NO to the cerebellar cortical locomotion area. This finding supports the view that NO in the cerebellum plays a key role in motor learning.
摘要
一氧化氮（NO）在细胞功能中具有多种作用，并且已经证明它参与小脑浦肯野细胞的长时程抑制的诱导。因此，对小脑组织中NO浓度或其合成的操控提供了一种在细胞和行为水平上研究NO在小脑功能中作用的方法。我们测试了猫对运动扰动的适应性控制，发现通过向小脑皮质运动区应用一氧化氮合酶抑制剂或一氧化氮清除剂，这种形式的运动学习被消除了。这一发现支持了小脑一氧化氮在运动学习中起关键作用的观点。
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