Bawaskar H S, Bawaskar P H
Bawaskar Hospital and Research Centre, Mahad Raigad, Maharashtra, India.
QJM. 1996 Sep;89(9):701-4. doi: 10.1093/qjmed/89.9.701.
We describe the clinical course and outcome in 46 victims of severe scorpion envenoming treated with prazosin (P), and compare them with earlier patients treated with conventional therapy (C) (n = 45) and nifepidine (N) (n = 28). The incidence of complicating left ventricular failure was 29% for C, 35% for N and 6.5% for P; that of acute pulmonary oedema was 46% for C, 14% for N and zero for P; mortality was 25% for C, 3.5% for N and zero for P. Although this is a historical study, prazosin appears to significantly reduce morbidity and shorten recovery time. Experience in other countries suggests that antivenom is helpful in controlling many of these problems, but in rural India serotherapy remains largely unavailable, and prazosin is a mainstay of treatment.
我们描述了46例接受哌唑嗪（P）治疗的严重蝎螫伤患者的临床病程和转归，并将其与早期接受传统疗法（C）（n = 45）和硝苯地平（N）（n = 28）治疗的患者进行比较。C组并发左心室衰竭的发生率为29%，N组为35%，P组为6.5%；急性肺水肿的发生率C组为46%，N组为14%，P组为零；死亡率C组为25%，N组为3.5%，P组为零。尽管这是一项历史性研究，但哌唑嗪似乎能显著降低发病率并缩短恢复时间。其他国家的经验表明，抗蛇毒血清有助于控制其中许多问题，但在印度农村，血清疗法仍然基本无法获得，哌唑嗪是主要的治疗药物。
