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在掺入溴脱氧尿苷之前，暴露于8-甲氧基补骨脂素和长波紫外线辐射的人淋巴细胞中的姐妹染色单体交换。

Sister chromatid exchanges in human lymphocytes exposed to 8-methoxypsoralen and long wave UV radiation prior to incorporation of bromodeoxyuridine.

作者信息

Mourelatos D, Faed M J, Johnson B E

出版信息

Experientia. 1977 Aug 15;33(8):1091-3. doi: 10.1007/BF01945989.

DOI:10.1007/BF01945989
PMID:891823
Abstract

Human lymphocytes exposed to the effects of long wave UV radiation in the presence of 8-methoxypsoralen prior to stimulation by PHA show dose related sister chromatid exchanges after 2 replication cycles in vitro. This has implications for interpreting the processes involved and for monitoring DNA damaging agents in vivo.

摘要

在体外经两次复制周期后，在被PHA刺激之前，暴露于长波紫外线辐射并存在8-甲氧基补骨脂素作用下的人淋巴细胞显示出与剂量相关的姐妹染色单体交换。这对于解释其中涉及的过程以及监测体内DNA损伤剂具有重要意义。

相似文献

1
Sister chromatid exchanges in human lymphocytes exposed to 8-methoxypsoralen and long wave UV radiation prior to incorporation of bromodeoxyuridine.在掺入溴脱氧尿苷之前，暴露于8-甲氧基补骨脂素和长波紫外线辐射的人淋巴细胞中的姐妹染色单体交换。
Experientia. 1977 Aug 15;33(8):1091-3. doi: 10.1007/BF01945989.
2
8-methoxypsoralen and UVA promote sister-chromatid exchanges.8-甲氧基补骨脂素与紫外线A可促进姐妹染色单体交换。
J Invest Dermatol. 1976 Oct;67(4):548-51. doi: 10.1111/1523-1747.ep12664558.
3
Sister chromatid exchanges in lymphocytes of psoriatics after treatment with 8-methoxypsoralen and long wave ultraviolet radiation.用8-甲氧基补骨脂素和长波紫外线辐射治疗后银屑病患者淋巴细胞中的姐妹染色单体交换
Br J Dermatol. 1977 Dec;97(6):649-54. doi: 10.1111/j.1365-2133.1977.tb14272.x.
4
Comparison of sister-chromatid exchange induced by photoactivated 3-carbethoxypsoralen and 8-methoxypsoralen in human blood lymphocytes.光活化的3-乙氧羰基补骨脂素和8-甲氧基补骨脂素在人血淋巴细胞中诱导的姐妹染色单体交换的比较。
Mutat Res. 1985 Nov-Dec;152(2-3):211-5. doi: 10.1016/0027-5107(85)90063-6.
5
Greater promotion in sister chromatid exchanges by trimethylpsoralen than by 8-methoxypsoralen in the presence of UV-light.在紫外线存在的情况下，三甲基补骨脂素比8-甲氧基补骨脂素对姐妹染色单体交换的促进作用更强。
J Invest Dermatol. 1978 Oct;71(4):257-9. doi: 10.1111/1523-1747.ep12515098.
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Sister chromatid exchange frequency in human epidermal cells in culture treated with 8-methoxypsoralen and long-wave UV radiation.
J Invest Dermatol. 1982 Jan;78(1):67-8. doi: 10.1111/1523-1747.ep12497941.
7
Characterization of sister chromatid exchange induction by 8-methoxypsoralen plus near UV light.
Cytogenet Cell Genet. 1978;21(4):184-200. doi: 10.1159/000130896.
8
Dose-effects of 8-methoxypsoralen and UVA in cultured human lymphocytes.
Br J Dermatol. 1978 Feb;98(2):141-4. doi: 10.1111/j.1365-2133.1978.tb01614.x.
9
Acute effect of 8-methoxypsoralen and ultraviolet light on sister chromatid exchange.8-甲氧基补骨脂素与紫外线对姐妹染色单体交换的急性效应
Arch Dermatol Res. 1978 Sep 28;263(1):37-46.
10
Bromodeoxyuridine-induced sister chromatid exchanges in human lymphocytes.溴脱氧尿苷诱导人淋巴细胞中的姐妹染色单体交换
Hereditas. 1976;83(2):163-74. doi: 10.1111/j.1601-5223.1976.tb01582.x.

引用本文的文献

1
The effect of 8-methoxypsoralen and longwave UV-radiation on growth rates of human epidermal cells in culture.
Experientia. 1983 Feb 15;39(2):186-7. doi: 10.1007/BF01958891.
2
Psoralen/UVA treatment and chromosomes. II. Analyses of psoriasis patients.补骨脂素/紫外线A光疗法与染色体。II. 银屑病患者分析
Arch Dermatol Res. 1978 May 31;261(3):287-94. doi: 10.1007/BF00455298.
3
Sister chromatid exchange in lymphocytes from patients with malignant lymphoma.恶性淋巴瘤患者淋巴细胞中的姐妹染色单体交换

本文引用的文献

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EVIDENCES OF A PHOTOREACTION OF THE PHOTOSENSITIZING FUROCOUMARINS WITH DNA AND WITH PYRIMIDINE NUCLEOSIDES AND NUCLEOTIDES.光敏呋喃香豆素与DNA、嘧啶核苷及核苷酸发生光反应的证据
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MITOMYCINS AND PORFIROMYCIN: CHEMICAL MECHANISM OF ACTIVATION AND CROSS-LINKING OF DNA.丝裂霉素和卟吩姆：DNA激活与交联的化学机制
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Psoralen monoadducts and interstrand cross-links in DNA.补骨脂素在DNA中的单加合物和链间交联。
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Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.在呋喃香豆素（补骨脂素）存在的情况下，光诱导DNA交联。用λ噬菌体、大肠杆菌和小鼠白血病细胞进行的研究。
Biochim Biophys Acta. 1970 Sep 17;217(1):30-9. doi: 10.1016/0005-2787(70)90119-x.
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Environmental mutagenesis and repair.
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Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.口服甲氧沙林与长波紫外线光化学疗法治疗银屑病
N Engl J Med. 1974 Dec 5;291(23):1207-11. doi: 10.1056/NEJM197412052912301.
7
New Giemsa method for the differential staining of sister chromatids.用于姐妹染色单体鉴别染色的新吉姆萨方法。
Nature. 1974 Sep 13;251(5471):156-8. doi: 10.1038/251156a0.
8
Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C.姐妹染色单体交换，人类染色体损伤与修复的指标：通过荧光检测及丝裂霉素C诱导
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3162-6. doi: 10.1073/pnas.71.8.3162.
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Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes.人中期染色体中脱氧核糖核酸复制的显微荧光检测
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3395-9. doi: 10.1073/pnas.70.12.3395.
10
The human leukocyte test system. VI. The use of sister chromatid exchanges as possible indicators for mutagenic activities.人类白细胞检测系统。VI. 利用姐妹染色单体交换作为诱变活性的可能指标。
Humangenetik. 1975 Sep 10;29(2):127-34. doi: 10.1007/BF00430349.