在掺入溴脱氧尿苷之前，暴露于8-甲氧基补骨脂素和长波紫外线辐射的人淋巴细胞中的姐妹染色单体交换。
Sister chromatid exchanges in human lymphocytes exposed to 8-methoxypsoralen and long wave UV radiation prior to incorporation of bromodeoxyuridine.
作者信息
Mourelatos D, Faed M J, Johnson B E
出版信息
Experientia. 1977 Aug 15;33(8):1091-3. doi: 10.1007/BF01945989.
PMID:891823
Abstract
Human lymphocytes exposed to the effects of long wave UV radiation in the presence of 8-methoxypsoralen prior to stimulation by PHA show dose related sister chromatid exchanges after 2 replication cycles in vitro. This has implications for interpreting the processes involved and for monitoring DNA damaging agents in vivo.
摘要
在体外经两次复制周期后，在被PHA刺激之前，暴露于长波紫外线辐射并存在8-甲氧基补骨脂素作用下的人淋巴细胞显示出与剂量相关的姐妹染色单体交换。这对于解释其中涉及的过程以及监测体内DNA损伤剂具有重要意义。
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