Hultberg B, Isaksson A, Lindgren A, Israelsson B, Brattstrom L
Department of Clinical Chemistry, University Hospital, Lund, Sweden.
Clin Chim Acta. 1996 Jan 15;244(1):35-44. doi: 10.1016/0009-8981(95)06176-2.
We determined plasma activity of the isoenzymes of beta-hexosaminidase (Hex) in 151 patients with cerebral infarction, since earlier findings have shown a relation between Hex isoenzymes and risk factors for vascular disease in normal subjects. Compared with 206 control subjects, an elevated level of plasma Hex isoenzymes was found in patients with cerebral infarction, particularly females. However, there was no relation to the clinical subtypes of diagnosis or to the presence of any risk factors for vascular disease, such as carotid artery stenosis, major potential cardio-embolic risk factors on echocardiography, hypertension, heart disease, diabetes mellitus or tobacco smoking. Instead, our findings indicate that Hex isoenzymes in patients with cerebral infarction are more influenced by the level of serum aspartate aminotransferase and blood glucose. The main conclusion is that the liver function as reflected by the level of liver enzymes and glucose metabolism are the major determinants of Hex isoenzymes in plasma.
我们测定了151例脑梗死患者血浆中β-己糖胺酶（Hex）同工酶的活性，因为早期研究结果表明Hex同工酶与正常受试者血管疾病的危险因素之间存在关联。与206名对照受试者相比，脑梗死患者血浆Hex同工酶水平升高，尤其是女性。然而，这与诊断的临床亚型或血管疾病的任何危险因素的存在无关，如颈动脉狭窄、超声心动图上主要的潜在心脏栓塞危险因素、高血压、心脏病、糖尿病或吸烟。相反，我们的研究结果表明，脑梗死患者的Hex同工酶受血清天冬氨酸转氨酶水平和血糖的影响更大。主要结论是，肝酶水平和葡萄糖代谢所反映的肝功能是血浆中Hex同工酶的主要决定因素。
