Tragnone A, Corrao G, Miglio F, Caprilli R, Lanfranchi G A
Institute of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy.
Int J Epidemiol. 1996 Oct;25(5):1044-52. doi: 10.1093/ije/25.5.1044.
The epidemiology of inflammatory bowel disease (IBD) in Southern Europe is still unclear. Sporadic reports suggest a lower incidence of IBD in Italy than in other Western Countries and the USA.
A nationwide population-based study was carried out to estimate IBD incidence rates in eight Italian cities. All new cases of IBD diagnosed over 4 years in the target populations were collected from multiple information sources.
From 1989 to 1992, 509 ulcerative colitis (UC), 222 Crohn's disease (CD) and 10 undefined IBD cases were collected, giving age-adjusted incidence rates (per 100,000 per year) of 5.2 for UC and 2.3 for CD. Using the capture-recapture method, an estimated completeness of 0.81 was obtained for case archives, without appreciable and significant differences between areas. The rates computed after correcting underestimation were 6.8 for UC and 2.8 for CD. The sex ratio M/F was 1.7 for UC and 1.0 for CD. The highest age-specific incidence rates were between 30 and 39 years for UC and between 20 and 29 years for CD.
The incidence rate of CD in italy is homogeneous between the cities investigated and lower than those reported for other Mediterranean countries. In contrast, the UC incidence rate is within the range of those reported in European studies. A wide variability in the UC rates between the cities was also observed. These results could be related to different environmental factors or the genetic background of the populations, or both.
南欧炎症性肠病（IBD）的流行病学情况仍不明确。零星报告显示，意大利IBD的发病率低于其他西方国家及美国。
开展了一项基于全国人口的研究，以估算意大利八个城市的IBD发病率。从多个信息来源收集目标人群中4年内诊断出的所有IBD新病例。
1989年至1992年，共收集到509例溃疡性结肠炎（UC）、222例克罗恩病（CD）及10例未明确的IBD病例，UC的年龄调整发病率（每年每10万人）为5.2，CD为2.3。采用捕获再捕获法，病例档案的估计完整性为0.81，各地区之间无明显显著差异。校正低估后计算出的发病率，UC为6.8，CD为2.8。UC的男女比例为1.7，CD为1.0。UC年龄别发病率最高的年龄段为30至39岁，CD为20至29岁。
在所调查的意大利各城市中，CD的发病率较为一致，且低于其他地中海国家报告的发病率。相比之下，UC发病率在欧洲研究报告的范围内。各城市之间UC发病率也存在很大差异。这些结果可能与不同的环境因素或人群的遗传背景，或两者都有关。
