Ritenbaugh C, Peng Y M, Aickin M, Graver E, Branch M, Alberts D S
Department of Family and Community Medicine, University of Arizona Health Sciences Center, Tucson 85724, USA.
Cancer Epidemiol Biomarkers Prev. 1996 Nov;5(11):907-12.
Carotenoid consumption is of great interest in disease prevention studies. Until recently, carotenoid food composition data have not been available from a single laboratory source with high validity/reliability characteristics. With the availability of a new carotenoid food composition data base, we examined the impact of the new data base on the intake estimates as measured by a food frequency questionnaire and on the relationship of those estimates to plasma values to ascertain what, if any, improvement is achieved through use of the new values. Plasma samples were available for 162 healthy adults participating in cancer prevention studies at the Arizona Cancer Center, including men and women, smokers and nonsmokers. A single laboratory analyzed plasma samples for beta-carotene, alpha-carotene, lutein, and lycopene. All subjects had completed a modified version of the Block food frequency questionnaire, which calculates carotenoids using a literature-based algorithm. A new carotenoid composition data base using recently published data (A.R. Mangels et al., J. Am. Diet. Assoc., 93: 284-296, 1993) was then directly substituted for the Block data base. There were high correlations between intake estimates derived from the two data bases for all four carotenoids (range, r = 0.76-0.96). Average intake estimates based on the Mangels et al. data base were significantly higher for beta-carotene and lycopene; however, correlations between intakes and plasma values were significantly different only for beta-carotene (r = 0.44 for Mangels versus 0.32 for Block, P = 0.015).
类胡萝卜素的摄入量在疾病预防研究中备受关注。直到最近，还没有来自单一实验室且具有高有效性/可靠性特征的类胡萝卜素食物成分数据。随着一个新的类胡萝卜素食物成分数据库的出现，我们研究了这个新数据库对通过食物频率问卷测量的摄入量估计值的影响，以及这些估计值与血浆值之间的关系，以确定使用新值是否能带来任何改善。162名参与亚利桑那癌症中心癌症预防研究的健康成年人（包括男性和女性、吸烟者和非吸烟者）提供了血浆样本。一个实验室对血浆样本中的β-胡萝卜素、α-胡萝卜素、叶黄素和番茄红素进行了分析。所有受试者都完成了一份经过修改的布洛克食物频率问卷，该问卷使用基于文献的算法计算类胡萝卜素含量。然后，直接用一个使用最近公布数据（A.R. 曼格斯等人，《美国饮食协会杂志》，93: 284 - 296, 1993）的新类胡萝卜素成分数据库替代了布洛克数据库。对于所有四种类胡萝卜素，两个数据库得出的摄入量估计值之间都存在高度相关性（范围，r = 0.76 - 0.96）。基于曼格斯等人数据库的β-胡萝卜素和番茄红素的平均摄入量估计值显著更高；然而，摄入量与血浆值之间的相关性仅在β-胡萝卜素方面有显著差异（曼格斯数据库的r = 0.44，布洛克数据库的r = 0.32，P = 0.015）。
