Michaud D S, Giovannucci E L, Ascherio A, Rimm E B, Forman M R, Sampson L, Willett W C
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):283-90.
Diet-plasma carotenoid associations were examined in samples of women and men from each cohort in the Nurses' Health Study and the Health Professionals Follow-Up Study. In each sample, participants completed two self-administered food frequency questionnaires with at least a 1-year interval and provided a blood specimen preceding the second food frequency questionnaire. Carotenoid intakes were estimated from values for the five major carotenoids found in human plasma, specifically, alpha- and beta-carotene, beta-cryptoxanthin, lutein, and lycopene, using the United States Department of Agriculture-National Cancer Institute Carotenoid Database, as well as updated values for tomato products. Pearson correlation coefficients were calculated to compare diet-plasma correlations over time by sex after adjustment for recognized covariates. Among nonsmoking women (n = 162), the adjusted diet-plasma carotenoid associations were 0.48 for alpha-carotene, 0.27 for beta-carotene and lutein, 0.32 for beta-cryptoxanthin, and 0.21 for lycopene. Among nonsmoking men (n = 110), diet-plasma correlations were 0.47 for alpha-carotene and lycopene, 0.35 for beta-carotene, 0.43 for beta-cryptoxanthin, and 0.40 for lutein. Correlations between total fruit or vegetable intake and each plasma carotenoid level were not as high as any of the calculated carotenoid intake using the new database values. The correlations observed in this study indicate that the new carotenoid database provides valuable information on specific carotenoid intake and may be useful in epidemiological studies that attempt to account for associations between fruit or vegetable intake and disease.
在护士健康研究和卫生专业人员随访研究的每个队列中，对女性和男性样本的饮食与血浆类胡萝卜素之间的关联进行了研究。在每个样本中，参与者完成了两份至少间隔1年的自填式食物频率问卷，并在第二次食物频率问卷之前提供了一份血液样本。使用美国农业部 - 国家癌症研究所类胡萝卜素数据库以及番茄制品的更新值，根据在人体血浆中发现的五种主要类胡萝卜素（即α-和β-胡萝卜素、β-隐黄质、叶黄素和番茄红素）的值来估计类胡萝卜素摄入量。计算Pearson相关系数，以在调整公认的协变量后，按性别比较不同时间的饮食与血浆的相关性。在不吸烟的女性（n = 162）中，调整后的饮食与血浆类胡萝卜素关联中，α-胡萝卜素为0.48，β-胡萝卜素和叶黄素为0.27，β-隐黄质为0.32，番茄红素为0.21。在不吸烟的男性（n = 110）中，饮食与血浆的相关性为，α-胡萝卜素和番茄红素为0.47，β-胡萝卜素为0.35，β-隐黄质为0.43，叶黄素为0.40。总水果或蔬菜摄入量与每种血浆类胡萝卜素水平之间的相关性不如使用新数据库值计算的任何类胡萝卜素摄入量高。本研究中观察到的相关性表明，新的类胡萝卜素数据库提供了有关特定类胡萝卜素摄入量的有价值信息，并且可能有助于那些试图解释水果或蔬菜摄入量与疾病之间关联的流行病学研究。
