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本文引用的文献

1
Inhibition of relaxations to nitrergic stimulation of the mouse anococcygeus by duroquinone.杜罗醌对小鼠肛门尾骨肌硝化能刺激引起的舒张的抑制作用。
Br J Pharmacol. 1995 Dec;116(8):3231-6. doi: 10.1111/j.1476-5381.1995.tb15129.x.
2
Inhibition of non-adrenergic non-cholinergic relaxations by nitric oxide donors.一氧化氮供体对非肾上腺素能非胆碱能舒张的抑制作用。
Eur J Pharmacol. 1995 Oct 24;285(3):269-74. doi: 10.1016/0014-2999(95)00420-p.
3
Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.一氧化氮捕获剂羧基-PTIO对一氧化氮与氮能递质的区分作用，但对一氧化氮与内皮舒张因子无区分作用。
Br J Pharmacol. 1995 Sep;116(2):1906-10. doi: 10.1111/j.1476-5381.1995.tb16681.x.
4
S-nitrosocysteine, but not sodium nitroprusside, produces apamin-sensitive hyperpolarization in rat gastric fundus.S-亚硝基半胱氨酸而非硝普钠可使大鼠胃底产生蜂毒明肽敏感的超极化。
Br J Pharmacol. 1993 Jun;109(2):415-23. doi: 10.1111/j.1476-5381.1993.tb13585.x.
5
Understanding the controversy over the identity of EDRF.了解关于内皮舒张因子（EDRF）身份的争议。
Nature. 1994 Mar 3;368(6466):62-5. doi: 10.1038/368062a0.
6
Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols.牛阴茎退缩肌的非肾上腺素能、非胆碱能舒张：S-亚硝基硫醇的作用
Br J Pharmacol. 1994 Apr;111(4):1287-95. doi: 10.1111/j.1476-5381.1994.tb14885.x.
7
Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.S-亚硝基硫醇与大鼠胃底硝酸盐耐受性的影响
Br J Pharmacol. 1994 Apr;111(4):1280-6. doi: 10.1111/j.1476-5381.1994.tb14884.x.
8
Biological activity of S-nitrosothiols: the role of nitric oxide.S-亚硝基硫醇的生物活性：一氧化氮的作用。
J Pharmacol Exp Ther. 1993 Dec;267(3):1529-37.
9
Smooth muscle relaxing effects of NO, nitrosothiols and a nerve-induced relaxing factor released in guinea-pig colon.一氧化氮、亚硝基硫醇及豚鼠结肠中释放的一种神经诱导舒张因子的平滑肌舒张作用
Br J Pharmacol. 1994 Dec;113(4):1088-92. doi: 10.1111/j.1476-5381.1994.tb17107.x.
10
NANC neurotransmission in the bovine retractor penis muscle is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate.在用二乙基二硫代氨基甲酸盐抑制超氧化物歧化酶后，超氧阴离子会阻断牛阴茎退缩肌中的非肾上腺素能非胆碱能神经传递。
Neuropharmacology. 1994 Nov;33(11):1293-301. doi: 10.1016/0028-3908(94)90029-9.

铜离子对大鼠胃底对硝化能神经递质一氧化氮（NO）和S-亚硝基硫醇舒张反应的影响。

Effect of Cu2+ on relaxations to the nitrergic neurotransmitter, NO and S-nitrosothiols in the rat gastric fundus.

作者信息

De Man J G, De Winter B Y, Boeckxstaens G E, Herman A G, Pelckmans P A

机构信息

Division of Gastroenterology, Faculty of Medicine, University of Antwerp (UIA), Antwerpen-Wilrijk, Belgium.

出版信息

Br J Pharmacol. 1996 Nov;119(5):990-6. doi: 10.1111/j.1476-5381.1996.tb15769.x.

DOI:10.1111/j.1476-5381.1996.tb15769.x
PMID:8922751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1915940/
Abstract
  1. The effects of addition of Cu2+ and chelation of Cu2+ were studied on relaxations in response to S-nitrosothiols and on relaxations to non-adrenergic non-cholinergic (NANC) nerve stimulation, nitric oxide (NO) and glyceryl trinitrate (GTN) in the rat gastric fundus. 2. The S-nitrosothiols S-nitroso-L-cysteine (NOCys, 1-300 nM), S-nitrosoglutathione (GSNO, 0.01-3 microM) and S-nitroso-N-acetyl-D,L-penicillamine (SNAP, 0.01-3 microM) induced concentration-dependent relaxations of the rat gastric fundus muscle strip. The relaxant potencies of the S-nitrosothiols were NOCys > SNAP > GSNO. Relaxations to NOCys were transient and comparable to those to NANC nerve stimulation and NO whereas relaxations to GSNO and SNAP were sustained. The relaxations to NOCys, GSNO and SNAP were significantly and concentration-dependently enhanced by CuSO4 (3-30 microM). The order of relaxant potency in the presence of CuSO4 was reversed to GSNO approximately SNAP > NOCys. 3. In the presence but not in the absence of 0.1 microM GSNO, CuSO4 (1 microM) induced a rapid and transient relaxation which was inhibited by the superoxide radical generator, pyrogallol (30 microM). CuCl2 but not FeSO4 mimicked the effect of CuSO4. 4. Electrical stimulation (0.5-8 Hz) of the rat gastric fundus strips induced frequency-dependent relaxations which were previously shown to be nitrergic in nature and which were not affected by CuSO4 (3-30 microM). Relaxations to NO (3-100 nM) and GTN (0.01-1 microM) were not affected by 3 and 10 microM CuSO4 but were inhibited by 30 microM CuSO4. 5. The Cu2+ chelator, bathocuproine (3-30 microM) significantly and concentration-dependently inhibited the relaxations to NOCys (0.01-3 microM), GSNO (0.01-10 microM) and SNAP (0.01-3 microM). The inhibitory effect of 10 microM bathocuproine was reversed by 3 microM CuSO4. 6. Bathocuproine (3-30 microM) had no effect on the relaxations to NANC nerve stimulation (0.5-8 Hz) or on the concentration-response curve to NO (0.01-0.3 microM), whereas relaxations to GTN (0.01-1 microM) were significantly inhibited by 30 microM bathocuproine. 7. From these results we conclude that relaxations to S-nitrosothiols and to nitrergic stimulation of the rat gastric fundus are differentially affected by addition and chelation of Cu2+, suggesting that the nitrergic NANC neurotransmitter in the rat gastric fundus is not an S-nitrosothiol but is more likely to be free nitric oxide.
摘要
  1. 研究了添加Cu2+和螯合Cu2+对大鼠胃底对S-亚硝基硫醇的舒张反应以及对非肾上腺素能非胆碱能（NANC）神经刺激、一氧化氮（NO）和甘油三硝酸酯（GTN）的舒张反应的影响。2. S-亚硝基硫醇S-亚硝基-L-半胱氨酸（NOCys，1 - 300 nM）、S-亚硝基谷胱甘肽（GSNO，0.01 - 3 μM）和S-亚硝基-N-乙酰-D，L-青霉胺（SNAP，0.01 - 3 μM）可诱导大鼠胃底肌条浓度依赖性舒张。S-亚硝基硫醇的舒张效力为NOCys > SNAP > GSNO。对NOCys的舒张是短暂的，与对NANC神经刺激和NO的舒张相当，而对GSNO和SNAP的舒张是持续的。CuSO4（3 - 30 μM）显著且浓度依赖性地增强了对NOCys、GSNO和SNAP的舒张。在CuSO4存在下舒张效力的顺序颠倒为GSNO≈SNAP > NOCys。3. 在存在但不是不存在0.1 μM GSNO的情况下，CuSO4（1 μM）诱导快速且短暂的舒张，该舒张被超氧自由基生成剂邻苯三酚（30 μM）抑制。CuCl2而非FeSO4模拟了CuSO4的作用。4. 对大鼠胃底条的电刺激（0.5 - 8 Hz）诱导频率依赖性舒张，先前已证明其本质上是一氧化氮能的，且不受CuSO4（3 - 30 μM）影响。对NO（3 - 100 nM）和GTN（0.01 - 1 μM）的舒张不受3和10 μM CuSO4影响，但受30 μM CuSO4抑制。5. Cu2+螯合剂bathocuproine（3 - 30 μM）显著且浓度依赖性地抑制对NOCys（0.01 - 3 μM）、GSNO（0.01 - 10 μM）和SNAP（0.01 - 3 μM）的舒张。10 μM bathocuproine的抑制作用被3 μM CuSO4逆转。6. bathocuproine（3 - 30 μM）对NANC神经刺激（0.5 - 8 Hz）的舒张或对NO（0.01 - 0.3 μM）的浓度 - 反应曲线无影响，而对GTN（0.01 - 1 μM）的舒张被30 μM bathocuproine显著抑制。7. 从这些结果我们得出结论，大鼠胃底对S-亚硝基硫醇和对一氧化氮能刺激的舒张受到添加和螯合Cu2+的不同影响，表明大鼠胃底的一氧化氮能NANC神经递质不是S-亚硝基硫醇，而更可能是游离一氧化氮。