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2
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4
Comparative study of the quercetin, ascorbic acid, glutathione and superoxide dismutase for nitric oxide protecting effects in mouse gastric fundus.槲皮素、抗坏血酸、谷胱甘肽和超氧化物歧化酶对小鼠胃底一氧化氮保护作用的比较研究。
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S-nitrosothiols and the nitrergic neurotransmitter in the rat gastric fundus: effect of antioxidants and metal chelation.大鼠胃底中的S-亚硝基硫醇与氮能神经递质：抗氧化剂和金属螯合的作用
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Effects of pyrogallol, hydroquinone and duroquinone on responses to nitrergic nerve stimulation and NO in the rat anococcygeus muscle.连苯三酚、对苯二酚和杜醌对大鼠肛尾肌中一氧化氮能神经刺激反应及一氧化氮的影响。
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Antioxidant protection of NO-induced relaxations of the mouse anococcygeus against inhibition by superoxide anions, hydroquinone and carboxy-PTIO.一氧化氮（NO）诱导的小鼠肛门尾骨肌舒张的抗氧化保护作用，以抵抗超氧阴离子、对苯二酚和羧基-PTIO的抑制。
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The effects of superoxide anion generators on responses to exogenous nitric oxide and non-adrenergic, non-cholinergic nerve stimulation in rat isolated penile bulb.超氧阴离子生成剂对大鼠离体阴茎球部对外源性一氧化氮及非肾上腺素能、非胆碱能神经刺激反应的影响。
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Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus.次黄嘌呤/黄嘌呤氧化酶与猪胃底一氧化氮介导的舒张作用之间的相互作用。
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Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra.超氧阴离子生成剂和硫醇调节剂对绵羊尿道中一氧化氮能神经传递及对外源性一氧化氮舒张反应的影响。
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6
Effects of pyrogallol, hydroquinone and duroquinone on responses to nitrergic nerve stimulation and NO in the rat anococcygeus muscle.连苯三酚、对苯二酚和杜醌对大鼠肛尾肌中一氧化氮能神经刺激反应及一氧化氮的影响。
Br J Pharmacol. 1999 Jan;126(1):342-8. doi: 10.1038/sj.bjp.0702277.

本文引用的文献

1
Antioxidant enzymes in intramural nerves of the opossum esophagus.负鼠食管壁内神经中的抗氧化酶。
Am J Physiol. 1996 Jan;270(1 Pt 1):G136-42. doi: 10.1152/ajpgi.1996.270.1.G136.
2
Blockade of nitrergic transmission by hydroquinone, hydroxocobalamin and carboxy-PTIO in bovine retractor penis: role of superoxide anion.对苯二酚、羟钴胺素和羧基-PTIO对牛阴茎海绵体肌中一氧化氮能传递的阻断作用：超氧阴离子的作用
Br J Pharmacol. 1996 Apr;117(8):1633-8. doi: 10.1111/j.1476-5381.1996.tb15333.x.
3
Inhibition of relaxations to nitrergic stimulation of the mouse anococcygeus by duroquinone.杜罗醌对小鼠肛门尾骨肌硝化能刺激引起的舒张的抑制作用。
Br J Pharmacol. 1995 Dec;116(8):3231-6. doi: 10.1111/j.1476-5381.1995.tb15129.x.
4
Inhibition of non-adrenergic non-cholinergic relaxations by nitric oxide donors.一氧化氮供体对非肾上腺素能非胆碱能舒张的抑制作用。
Eur J Pharmacol. 1995 Oct 24;285(3):269-74. doi: 10.1016/0014-2999(95)00420-p.
5
Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.一氧化氮捕获剂羧基-PTIO对一氧化氮与氮能递质的区分作用，但对一氧化氮与内皮舒张因子无区分作用。
Br J Pharmacol. 1995 Sep;116(2):1906-10. doi: 10.1111/j.1476-5381.1995.tb16681.x.
6
S-nitrosocysteine, but not sodium nitroprusside, produces apamin-sensitive hyperpolarization in rat gastric fundus.S-亚硝基半胱氨酸而非硝普钠可使大鼠胃底产生蜂毒明肽敏感的超极化。
Br J Pharmacol. 1993 Jun;109(2):415-23. doi: 10.1111/j.1476-5381.1993.tb13585.x.
7
Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiols.牛阴茎退缩肌的非肾上腺素能、非胆碱能舒张：S-亚硝基硫醇的作用
Br J Pharmacol. 1994 Apr;111(4):1287-95. doi: 10.1111/j.1476-5381.1994.tb14885.x.
8
Influence of S-nitrosothiols and nitrate tolerance in the rat gastric fundus.S-亚硝基硫醇与大鼠胃底硝酸盐耐受性的影响
Br J Pharmacol. 1994 Apr;111(4):1280-6. doi: 10.1111/j.1476-5381.1994.tb14884.x.
9
NANC neurotransmission in the bovine retractor penis muscle is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate.在用二乙基二硫代氨基甲酸盐抑制超氧化物歧化酶后，超氧阴离子会阻断牛阴茎退缩肌中的非肾上腺素能非胆碱能神经传递。
Neuropharmacology. 1994 Nov;33(11):1293-301. doi: 10.1016/0028-3908(94)90029-9.
10
Models of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties.一氧化氮扩散传播模型：对神经一氧化氮信号传导及其药理学特性的影响。
Neuropharmacology. 1994 Nov;33(11):1235-44. doi: 10.1016/0028-3908(94)90022-1.

硫醇调节剂和铜/锌超氧化物歧化酶抑制对大鼠胃底一氧化氮能舒张的影响。

Effect of thiol modulators and Cu/Zn superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus.

作者信息

De Man J G, De Winter B Y, Boeckxstaens G E, Herman A G, Pelckmans P A

机构信息

Division of Gastroenterology, Faculty of Medicine, University of Antwerp (UIA), Antwerpen-Wilrijk, Belgium.

出版信息

Br J Pharmacol. 1996 Nov;119(5):1022-8. doi: 10.1111/j.1476-5381.1996.tb15773.x.

DOI:10.1111/j.1476-5381.1996.tb15773.x
PMID:8922754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1915936/
Abstract
  1. The effects of superoxide anion generators before and after treatment with inhibitors of Cu/Zn superoxide dismutase (Cu/Zn SOD) and the effects of thiol-modulating agents were investigated on nitrergic relaxations to electrical stimulation of non-adrenergic non-cholinergic (NANC) nerves of the rat gastric fundus and on relaxations to authentic nitric oxide (NO) and nitroglycerin. 2. The superoxide anion generators, pyrogallol (30 microM) and duroquinone (30-60 microM), significantly inhibited the relaxations to NO (0.03-3 microM) but not nitrergic relaxations to NANC nerve stimulation (0.5-8 Hz) or those to ATP (10 microM). Treatment of the rat gastric fundus with the inhibitors of Cu/Zn SOD, diethyldithiocarbamate (DETC, 1 mM for 2 h) or triethylenetetramine (TETA, 100 microM for 2 h) had no effect on the relaxations to NANC nerve stimulation (1-8 Hz), NO (0.03-3 microM) or on those to ATP (10 microM). 3. After treatment of the rat gastric fundus with DETC (1 mM) but not after treatment with TETA (100 microM), pyrogallol (30 microM) and duroquinone (30-60 microM) significantly inhibited the nitrergic relaxations to electrical stimulation (0.5-8 Hz) and those to NO (0.03-3 microM). This inhibitory effect of pyrogallol and duroquinone was prevented by addition of exogenous SOD (250 units ml-1). Pyrogallol but not duroquinone also inhibited the NO-independent relaxations to ATP (10 microM). 4. The thiol modulators, buthionine sulphoximine (1 mM for 2 h) and ethacrynic acid (30 microM for 2 h), significantly inhibited the relaxations to nitroglycerin (0.03-3 microM) but had no effect on the nitrergic relaxations to electrical stimulation (0.5-8 Hz) or on those to NO (0.03-10 microM) and ATP (10 microM). The thiol modulators, sulphobromophthalein (100 microM for 2 h) and diamide (30-100 microM for 2 h) did not affect the relaxations to nitroglycerin, or those to NANC nerve stimulation and NO. 5. In summary, thiol modulators significantly inhibited the thiol-dependent relaxations to nitroglycerin but not those to NANC nerve stimulation or NO. Relaxations to nitrergic stimulation were decreased by superoxide anion generators only after inhibition of Cu/Zn SOD. These results suggest that the nitrergic NANC neurotransmitter in the rat gastric fundus is not a nitrosothiol but more likely free NO, which is protected from breakdown by tissue SOD.
摘要
  1. 研究了超氧阴离子生成剂在经铜/锌超氧化物歧化酶（Cu/Zn SOD）抑制剂处理前后的作用，以及硫醇调节剂对大鼠胃底非肾上腺素能非胆碱能（NANC）神经电刺激引起的一氧化氮能舒张、对真实一氧化氮（NO）和硝酸甘油舒张的影响。2. 超氧阴离子生成剂连苯三酚（30微摩尔）和杜醌（30 - 60微摩尔）显著抑制对NO（0.03 - 3微摩尔）的舒张，但不抑制对NANC神经刺激（0.5 - 8赫兹）或对ATP（10微摩尔）的一氧化氮能舒张。用Cu/Zn SOD抑制剂二乙基二硫代氨基甲酸盐（DETC，1毫摩尔处理2小时）或三亚乙基四胺（TETA，100微摩尔处理2小时）处理大鼠胃底，对NANC神经刺激（1 - 8赫兹）、NO（0.03 - 3微摩尔）或对ATP（10微摩尔）的舒张均无影响。3. 用DETC（1毫摩尔）处理大鼠胃底后而非用TETA（100微摩尔）处理后，连苯三酚（30微摩尔）和杜醌（30 - 60微摩尔）显著抑制对电刺激（0.5 - 8赫兹）和对NO（0.03 - 3微摩尔）的一氧化氮能舒张。加入外源性SOD（250单位/毫升）可阻止连苯三酚和杜醌的这种抑制作用。连苯三酚而非杜醌也抑制对ATP（10微摩尔）的非NO依赖性舒张。4. 硫醇调节剂丁硫氨酸亚砜胺（1毫摩尔处理2小时）和依他尼酸（30微摩尔处理2小时）显著抑制对硝酸甘油（0.03 - 3微摩尔）的舒张，但对NANC神经电刺激（0.5 - 8赫兹）、对NO（0.03 - 10微摩尔）和ATP（10微摩尔）的一氧化氮能舒张无影响。硫醇调节剂磺溴酞（100微摩尔处理2小时）和二酰胺（30 - 100微摩尔处理2小时）不影响对硝酸甘油的舒张，也不影响对NANC神经刺激和NO的舒张。5. 总之，硫醇调节剂显著抑制对硝酸甘油的硫醇依赖性舒张，但不抑制对NANC神经刺激或NO的舒张。仅在抑制Cu/Zn SOD后，超氧阴离子生成剂才会降低对一氧化氮能刺激的舒张。这些结果表明，大鼠胃底的一氧化氮能NANC神经递质不是亚硝基硫醇，而更可能是游离NO，其受到组织SOD的保护而不被分解。