The recombinant outer surface protein A (lipOspA) of Borrelia burgdorferi: a Lyme disease vaccine.

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作者信息

Wallich R, Kramer M D, Simon M M

机构信息

Institut für Immunologie, Universität Heidelberg, Germany.

出版信息

Infection. 1996 Sep-Oct;24(5):396-7. doi: 10.1007/BF01716093.

DOI:10.1007/BF01716093

PMID:8923055

Abstract

摘要

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The recombinant outer surface protein A (lipOspA) of Borrelia burgdorferi: a Lyme disease vaccine.

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Immunization against Lyme disease--an important first step.莱姆病免疫接种——重要的第一步。

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Anti-OspA antibody reduces reservoir competence of mice for Borrelia burgdorferi, the agent of Lyme disease.抗OspA抗体降低了小鼠作为莱姆病病原体伯氏疏螺旋体储存宿主的能力。

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Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group.使用重组伯氏疏螺旋体外膜脂蛋白A加佐剂进行莱姆病疫苗接种。莱姆病疫苗研究组。

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Detection of multiple reactive protein species by immunoblotting after recombinant outer surface protein A lyme disease vaccination.重组外表面蛋白A莱姆病疫苗接种后通过免疫印迹法检测多种反应性蛋白种类

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A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium.一种由重组伯氏疏螺旋体外膜蛋白A组成的预防莱姆病的疫苗。重组外膜蛋白A莱姆病疫苗研究联盟。

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Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs.一种口服疫苗在小鼠和蜱虫宿主中降低伯氏疏螺旋体（菌株N40）携带率的保护效力。

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本文引用的文献

The outer surface protein A (OspA) of Borrelia burgdorferi: a vaccine candidate and bioactive mediator.伯氏疏螺旋体的外表面蛋白A（OspA）：一种候选疫苗和生物活性介质。

Infection. 1996 Mar-Apr;24(2):190-4. doi: 10.1007/BF01713338.

The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis.严重联合免疫缺陷（scid）小鼠。用于分析莱姆关节炎和心肌炎的实验室模型。

J Exp Med. 1989 Oct 1;170(4):1427-32. doi: 10.1084/jem.170.4.1427.

Lyme disease.莱姆病

N Engl J Med. 1989 Aug 31;321(9):586-96. doi: 10.1056/NEJM198908313210906.

Cloning and sequencing of the gene encoding the outer surface protein A (OspA) of a European Borrelia burgdorferi isolate.一株欧洲伯氏疏螺旋体分离株外表面蛋白A（OspA）编码基因的克隆与测序

Nucleic Acids Res. 1989 Nov 11;17(21):8864. doi: 10.1093/nar/17.21.8864.

Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi.在实验性接种伯氏疏螺旋体的小鼠中抗原特异性T细胞及组织病理学改变的证明

Infect Immun. 1989 Jan;57(1):41-7. doi: 10.1128/iai.57.1.41-47.1989.

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.针对伯氏疏螺旋体外表面蛋白A（OspA）的单克隆抗体可预防严重联合免疫缺陷（scid）小鼠的莱姆病。

Proc Natl Acad Sci U S A. 1990 May;87(10):3768-72. doi: 10.1073/pnas.87.10.3768.

Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver.莱姆病螺旋体病在严重联合免疫缺陷（scid）小鼠中主要表现在关节、心脏和肝脏。

Am J Pathol. 1990 Oct;137(4):811-20.

A mouse model for Borrelia burgdorferi infection: approach to a vaccine against Lyme disease.伯氏疏螺旋体感染的小鼠模型：抗莱姆病疫苗的研究方法

Immunol Today. 1991 Jan;12(1):11-6. doi: 10.1016/0167-5699(91)90106-4.

Recombinant outer surface protein a from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice.来自伯氏疏螺旋体的重组外表面蛋白a可诱导产生对小鼠螺旋体感染具有保护作用的抗体。

J Infect Dis. 1991 Jul;164(1):123-32. doi: 10.1093/infdis/164.1.123.

Myositis in mice inoculated with Borrelia burgdorferi.接种伯氏疏螺旋体的小鼠中的肌炎

Am J Pathol. 1991 Dec;139(6):1267-71.

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