Falini A, Calabrese G, Origgi D, Lipari S, Triulzi F, Losa M, Scotti G
Neuroradiology Department, Scientific Institute S. Raffaele Hospital, Milan, Italy.
J Neurol. 1996 Oct;243(10):706-14. doi: 10.1007/BF00873976.
Proton magnetic resonance spectroscopy (1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylasparate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neoplasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.
质子磁共振波谱（1H-MRS）被用于表征不同组织学类型的颅内肿瘤。70例颅内肿瘤患者在接受手术、放疗或化疗之前接受了研究。所有肿瘤均表现为N-乙酰天门冬氨酸减少或缺失，以及含胆碱化合物的信号增加。仅在原始脑肿瘤中观察到独特的模式；高级别胶质瘤通过含胆碱化合物的较高水平与低级别胶质瘤区分开来。转移瘤的代谢特征与高级别胶质瘤相似。本文综述了这些结果，以及1H-MRS的局限性和未来应用。
