Pascual M, Schifferli J A
Renal Unit, Massachusetts General Hospital, Boston 02114, USA.
Infusionsther Transfusionsmed. 1995 Oct;22(5):310-5. doi: 10.1159/000223148.
To review the main characteristics of the 'immune complex (IC) transport system of erythrocytes', and its possible relevance for transfusion medicine.
Literature search, and results Of Studies performed in the laboratory of Dr J. Schifferli from 1986 to 1995.
Peer review journals and work relevant to the topic.
When antigen/antibody IC form in the presence of complement. C3b binds covalently to the complexes. Such opsonized complexes attach to cells bearing complement receptor 1 (CR1), which is mostly found on erythrocytes in the circulation. This allows IC to be transported through the circulation to the fixed macrophage system of the liver and spleen. In addition, C3b bound to the complexes is catabolized by factor 1 (with CR1 as a cofactor) so that the complement-activating properties of the complexes are reduced.
Complement and erythrocyte CR1 contribute to the safe and effective elimination of IC in humans. This physiologic system prevents IC deposition in the vessel walls.
综述红细胞“免疫复合物（IC）转运系统”的主要特征及其与输血医学的潜在相关性。
文献检索以及1986年至1995年在J. Schifferli博士实验室进行的研究结果。
同行评审期刊以及与该主题相关的研究。
当抗原/抗体IC在补体存在的情况下形成时，C3b共价结合到复合物上。这种调理后的复合物附着于带有补体受体1（CR1）的细胞上，CR1主要存在于循环中的红细胞上。这使得IC能够通过循环转运至肝脏和脾脏的固定巨噬细胞系统。此外，结合到复合物上的C3b被因子1（以CR1作为辅助因子）分解代谢，从而降低复合物的补体激活特性。
补体和红细胞CR1有助于人体安全有效地清除IC。该生理系统可防止IC沉积于血管壁。
