新生大鼠血浆脂蛋白和肝脏脂质的变化

Changes in plasma lipoproteins and liver lipids in neonatal rats.

作者信息

García-Molina V, Aguilera J A, Gil A, Sánchez-Pozo A

机构信息

Department of Biochemistry and Molecular Biology, University of Granada, Spain.

出版信息

Comp Biochem Physiol B Biochem Mol Biol. 1996 Apr;113(4):789-93. doi: 10.1016/0305-0491(95)02115-9.

DOI:10.1016/0305-0491(95)02115-9

PMID:8925446

Abstract

Transient increases in triglycerides and cholesterol were found in rat liver immediately after birth. Plasma VLDL and HDL increased after birth and reached a plateau after one week of life. The content of cholesterol ester was low at birth in all lipoproteins and increased in LDL and HDL during the first week of life. After birth, VLDL became enriched in apolipoproteins C and E, whereas HDL was enriched in apolipoprotein C and depressed in apolipoprotein E. The developmental changes in plasma lipoprotein levels and compositions in rats during the first week of life are comparable to those described in humans.

摘要

出生后立即在大鼠肝脏中发现甘油三酯和胆固醇短暂升高。出生后血浆极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL）升高，并在出生一周后达到平台期。所有脂蛋白中的胆固醇酯含量在出生时较低，并在出生后第一周内在低密度脂蛋白（LDL）和高密度脂蛋白中增加。出生后，VLDL富含载脂蛋白C和E，而HDL富含载脂蛋白C且载脂蛋白E含量降低。大鼠出生后第一周血浆脂蛋白水平和组成的发育变化与人类描述的情况相当。