选择性IgA缺乏症与克罗恩病：两例报告。
Selective IgA deficiency and Crohn's disease: report of two cases.
作者信息
Hodgson H J, Jewell D P
出版信息
Gut. 1977 Aug;18(8):644-6. doi: 10.1136/gut.18.8.644.
Abstract
Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The typical clinical course and histology in these two patients suggest that IgA-mediated responses in the mucosa are not involved in the pathogenesis of Crohn's disease.
摘要
描述了两名患有克罗恩病和选择性IgA缺乏症的患者。在每个病例中血清IgA均无法检测到，固有层的免疫过氧化物酶研究显示含IgA浆细胞明显减少。然而，外周血淋巴细胞中含IgA淋巴细胞数量正常。这两名患者典型的临床病程和组织学表现提示，黏膜中IgA介导的反应不参与克罗恩病的发病机制。
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