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1
Induction of heat shock protein 60 expression in human monocytic cell lines infected with Mycobacterium leprae.麻风分枝杆菌感染的人单核细胞系中热休克蛋白60表达的诱导
Infect Immun. 1996 Oct;64(10):4356-8. doi: 10.1128/iai.64.10.4356-4358.1996.
2
Molecular basis of the defective heat stress response in Mycobacterium leprae.麻风分枝杆菌热应激反应缺陷的分子基础。
J Bacteriol. 2007 Dec;189(24):8818-27. doi: 10.1128/JB.00601-07. Epub 2007 Oct 12.
3
Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein.氧化型低密度脂蛋白诱导单核细胞中热休克蛋白的产生。
Atherosclerosis. 1996 Mar;121(1):93-103. doi: 10.1016/0021-9150(95)05706-4.
4
Induction of human hsp60 expression in monocytic cell lines.在单核细胞系中诱导人热休克蛋白60（hsp60）表达。
Int Immunol. 1992 Mar;4(3):305-11. doi: 10.1093/intimm/4.3.305.
5
M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression.麻风分枝杆菌通过下调Bad和Bak以及上调Mcl-1基因表达来抑制THP-1细胞中的细胞凋亡。
BMC Microbiol. 2006 Sep 18;6:78. doi: 10.1186/1471-2180-6-78.
6
Identification of promiscuous epitopes from the Mycobacterial 65-kilodalton heat shock protein recognized by human CD4(+) T cells of the Mycobacterium leprae memory repertoire.从麻风分枝杆菌记忆库中人类CD4(+) T细胞识别的分枝杆菌65千道尔顿热休克蛋白中鉴定混杂表位。
Infect Immun. 1999 Nov;67(11):5683-9. doi: 10.1128/IAI.67.11.5683-5689.1999.
7
Intracellular signals triggered during association of Mycobacterium leprae and Mycobacterium bovis BCG with human monocytes.麻风分枝杆菌和牛分枝杆菌卡介苗与人类单核细胞结合过程中触发的细胞内信号。
Microb Pathog. 2001 Jul;31(1):37-45. doi: 10.1006/mpat.2001.0444.
8
Mycobacterium bovis BCG but not Mycobacterium leprae induces TNF-alpha secretion in human monocytic THP-1 cells.牛分枝杆菌卡介苗可诱导人单核细胞THP-1细胞分泌肿瘤坏死因子-α，但麻风分枝杆菌则不能。
Mem Inst Oswaldo Cruz. 2001 Oct;96(7):973-8. doi: 10.1590/s0074-02762001000700015.
9
Human T cells recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: studies with healthy subjects vaccinated with Mycobacterium bovis BCG and Mycobacterium leprae.人类T细胞在多种HLA - DR分子的背景下识别分枝杆菌热休克蛋白：对接种牛分枝杆菌卡介苗和麻风分枝杆菌的健康受试者的研究。
Infect Immun. 1993 Dec;61(12):5294-301. doi: 10.1128/iai.61.12.5294-5301.1993.
10
Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence.嗜肺军团菌应激蛋白Hsp60在人单核细胞和L929细胞感染早期水平升高与毒力相关。
Infect Immun. 1996 Jun;64(6):1968-76. doi: 10.1128/iai.64.6.1968-1976.1996.

本文引用的文献

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Induction of heat-shock proteins by bacterial toxins, lipid mediators and cytokines in human leukocytes.细菌毒素、脂质介质和细胞因子在人白细胞中诱导热休克蛋白的产生。
Zentralbl Bakteriol. 1993 Apr;278(2-3):365-76. doi: 10.1016/s0934-8840(11)80853-4.
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Heat shock response to vaccinia virus infection.对痘苗病毒感染的热休克反应
J Virol. 1994 Jul;68(7):4685-9. doi: 10.1128/JVI.68.7.4685-4689.1994.
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Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation.人热休克蛋白60：细菌表达、纯化、单克隆抗体的研制及用于定量的夹心酶联免疫吸附测定法
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Infection of human and murine macrophages with Leishmania major is associated with early parasite heat shock protein synthesis but fails to induce a host cell stress response.利什曼原虫主要亚种感染人和小鼠巨噬细胞与早期寄生虫热休克蛋白合成有关，但未能诱导宿主细胞应激反应。
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Induction of heat shock gene expression in colonic epithelial cells after incubation with Escherichia coli or endotoxin.用大肠杆菌或内毒素孵育后结肠上皮细胞中热休克基因表达的诱导。
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Collection method for Mycobacterium leprae from infected armadillo liver.从感染犰狳肝脏中采集麻风分枝杆菌的方法。
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7
Definition of species specific and cross-reactive antigenic determinants of Mycobacterium leprae using monoclonal antibodies.利用单克隆抗体对麻风分枝杆菌种特异性及交叉反应性抗原决定簇的定义
Clin Exp Immunol. 1983 Jun;52(3):528-36.
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The immunobiology of leprosy.麻风病的免疫生物学
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Immunology of leprosy: new findings, future perspectives.麻风病免疫学：新发现与未来展望
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10
70K heat shock related proteins stimulate protein translocation into microsomes.70K热休克相关蛋白刺激蛋白质转运至微粒体中。
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麻风分枝杆菌感染的人单核细胞系中热休克蛋白60表达的诱导

Induction of heat shock protein 60 expression in human monocytic cell lines infected with Mycobacterium leprae.

作者信息

Beimnet K, Söderström K, Jindal S, Grönberg A, Frommel D, Kiessling R

机构信息

Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

出版信息

Infect Immun. 1996 Oct;64(10):4356-8. doi: 10.1128/iai.64.10.4356-4358.1996.

DOI:10.1128/iai.64.10.4356-4358.1996
PMID:8926111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174379/
Abstract

Monocytic cell lines (HL-60 and THP-1) were infected with viable Mycobacterium leprae. Levels of human hsp60 were estimated by Western blot (immunoblot) assay and a sandwich enzyme-linked immunosorbent assay. The results showed that infection of both of the cell lines induced the synthesis of human hsp60, which may be of significance in relation to autoimmune manifestations associated with mycobacterial infections.

摘要

单核细胞系（HL-60和THP-1）用活的麻风分枝杆菌进行感染。通过蛋白质免疫印迹（免疫印迹）分析和夹心酶联免疫吸附测定法评估人热休克蛋白60（hsp60）的水平。结果显示，两种细胞系的感染均诱导了人hsp60的合成，这可能与分枝杆菌感染相关的自身免疫表现具有相关性。