麻风分枝杆菌感染的人单核细胞系中热休克蛋白60表达的诱导
Induction of heat shock protein 60 expression in human monocytic cell lines infected with Mycobacterium leprae.
作者信息
Beimnet K, Söderström K, Jindal S, Grönberg A, Frommel D, Kiessling R
机构信息
Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
出版信息
Infect Immun. 1996 Oct;64(10):4356-8. doi: 10.1128/iai.64.10.4356-4358.1996.
Abstract
Monocytic cell lines (HL-60 and THP-1) were infected with viable Mycobacterium leprae. Levels of human hsp60 were estimated by Western blot (immunoblot) assay and a sandwich enzyme-linked immunosorbent assay. The results showed that infection of both of the cell lines induced the synthesis of human hsp60, which may be of significance in relation to autoimmune manifestations associated with mycobacterial infections.
摘要
单核细胞系（HL-60和THP-1）用活的麻风分枝杆菌进行感染。通过蛋白质免疫印迹（免疫印迹）分析和夹心酶联免疫吸附测定法评估人热休克蛋白60（hsp60）的水平。结果显示，两种细胞系的感染均诱导了人hsp60的合成，这可能与分枝杆菌感染相关的自身免疫表现具有相关性。
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